PMID: 6403653Apr 1, 1983Paper

Idiotype connectance in the immune system. I. Expression of a cross-reactive idiotype on induced anti-p-azophenylarsonate antibodies and on endogenous antibodies not specific for arsonate

The Journal of Experimental Medicine
P V Hornbeck, G K Lewis

Abstract

A new cross-reactive idiotope family (CRIAD8) is described that contains subpopulations of antibodies binding to different epitopes. One subpopulation occurs naturally in normal sera from strain A mice, is found mainly on IgG2 and IgG3 subclasses, does not bind p-azobenzenearsonate (ABA)+, does not express CRI5Ci, and can be selectively stimulated by low doses of antiidiotype antibody (AD8). The second subpopulation is not found in normal serum, binds ABA, is found on all IgG subclasses, expresses CRI5Ci, and is selectively stimulated by ABA-conjugated proteins. Since CRIAD8 was found on both subpopulations of antibody, and since each subpopulation could be selectively expanded, it was possible to study the effect that expansion of the ABA- CRIAD8+ set had on subsequent responses elicited by ABA-keyhole limpet hemocyanin (KLH) in the ABA+ CRIAD8+ set. In these experiments, prior immunization with AD8 restricted the subsequent response of the ABA+ CRIAD8+ set to ABA-KLH. Furthermore, only those doses of AD8 that stimulated the ABA-CRIAD8+ set reduced the responsiveness of the ABA+ CRIAD8+ set to ABA-KLH, suggesting that the two phenomena are causally related. These findings argue that CRIAD8 correlates well with a regulatory idi...Continue Reading

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J A LaskinP D Gottlieb
Dec 1, 1979·Molecular Immunology·E EnghoferM J Bosma
Oct 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·J Oudin, P A Cazenave
Apr 1, 1974·The Journal of Experimental Medicine·R LiebermanS Rudikoff
Jun 1, 1972·The Journal of Experimental Medicine·D A HartA Nisonoff
Jun 1, 1973·The Journal of Experimental Medicine·L L PawlakA Nisonoff
Jul 1, 1981·The Journal of Experimental Medicine·G G MillerD H Sachs
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·A Marshak-RothsteinM L Gefter
Jul 1, 1980·The Journal of Experimental Medicine·S T JuM E Dorf
May 1, 1964·The Journal of Experimental Medicine·D E OLINS, G M EDELMAN
Nov 1, 1979·Veterinary Immunology and Immunopathology·J Rousseaux, H Bazin

❮ Previous
Next ❯

Citations

Apr 13, 1984·Journal of Immunological Methods·G Di FeliceL Adorini
Dec 1, 1992·Molecular Immunology·G K Lewis, C P Feng
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T Manser, M L Gefter
Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J DurdikE Selsing
Feb 1, 1987·The Journal of Experimental Medicine·P MiglioriniR S Schwartz
Nov 6, 2009·The Journal of Experimental Medicine·Wesley A DunnickF Nina Papavasiliou
Jun 1, 1992·AIDS Research and Human Retroviruses·S KeayB S Handwerger
Jan 1, 1993·International Reviews of Immunology·J SharonS R Sompuram
Jul 1, 1991·Clinical Immunology and Immunopathology·J M Greally
Jan 1, 1986·Annals of the New York Academy of Sciences·S K Datta, J Gavalchin
May 1, 1990·European Journal of Immunology·T P MurphyT L Rothstein
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole D'AvirroErik Selsing
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher M SnyderLawrence J Wysocki
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wesley A DunnickJohn T Collins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.