PMID: 7019378May 1, 1981Paper

Idiotype profile of an immune response. I. Contrasts in idiotypic dominance between primary and secondary responses and between IgM and IgG plaque-forming cells

The Journal of Experimental Medicine
J D CongerJ W Goodman

Abstract

The primary response of A/J mice to p-azobenzenearsonate-keyhole limpet hemocyanin (ABA-KLH) was investigated. A day-by-day analysis at the plaque- forming cell (PFC) level was performed, with inhibition by anti-cross- reactive idiotype (CRI) serum to determine percentage of CRI(+) PFC. A regular pattern in the dynamics of Id (idiotype) dominance was observed. Just as in the NP-b and NP-a systems (9, 12), the major Id (CRI) is more dominant in primary than in secondary or hyperimmune responses. This trend is more apparent in IgG PFC which are generally 80-95 percent CRI(+) at day 10 in the primary response but only 30-40 percent CRI(+) at day 10 in secondary or hyperimmune responses. A somewhat different pattern is seen with IgM PFC. These may reach a peak of 85 percent CRI(+) in the primary response, but secondary or hyperimmune IgM PFC, which are lower in numbers than IgG PFC, remain high in CRI content at approximately 70 percent. The PFC data on extent of id dominance in secondary or hyperimmune responses is fully compatible with previously reported serological data by others. Analysis of IgG PFC by hapten inhibition indicated that heterogeneity was in the order secondary PFC {greater than} primary PFC {greater than} hybrid...Continue Reading

References

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Citations

Aug 1, 1982·Human Immunology·F C GrumetE G Engleman
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G M IversonR K Gershon
Sep 1, 1982·The Journal of Experimental Medicine·L Ortiz-OrtizD E Parks
Feb 1, 1984·The Journal of Clinical Investigation·A Saxon, E Barnett
Jul 1, 1989·Journal of Marital and Family Therapy·F J FloydR A Cimmarusti
Apr 1, 1986·Immunological Reviews·J A BluestoneD H Sachs
Dec 20, 2011·Brain, Behavior, and Immunity·Ludmila A GerlinskayaMikhail P Moshkin
Oct 1, 1982·European Journal of Immunology·J R HiernauxC Bona
Nov 1, 1983·European Journal of Immunology·D MaleI Roitt

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