PMID: 6973000Jun 1, 1981Paper

Idiotypes on major histocompatibility complex-restricted virus-immune cytotoxic T lymphocytes

The Journal of Experimental Medicine
U R Kees

Abstract

Specificity-associated determinants could be demonstrated on major histocompatibility complex (MHC)-restricted virus-immune cytotoxic T lymphocytes (CTL) using antisera raised in syngeneic mice. This result indicates that the number of clonotypes sufficiently small to allow the detection of such idiotypic determinants. The functional properties of three anti-idiotypic antisera were tested in blocking studies and by idiotypic antisera plus complement. Whereas the former test did not reveal any results obtained from binding studies, i.e., all three anti-idiotypic antisera specifically reacted with CTL of the type used for immunization and had no effect on syngeneic influenza-immune CTL, syngeneic alloreactive CTL, or NDV-immune CTL of an H-2-disparate strain. These results are discussed in terms of current models for MHC-restricted CTL responses.

References

Feb 1, 1976·The Journal of Experimental Medicine·U Kees, R V Blanden
Apr 1, 1979·The Journal of Experimental Medicine·H BinzH Wigzell
Jun 1, 1975·Journal of Immunological Methods·W F Davidson, C R Parish
Dec 1, 1978·The Journal of Experimental Medicine·U KeesR V Blanden
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Sep 1, 1980·The Journal of Experimental Medicine·T Hünig, M J Bevan
Sep 1, 1980·The Journal of Experimental Medicine·N HollanderI L Weissman

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Citations

Apr 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·S G EgorovaB D Brondz
Jan 1, 1983·Molecular Aspects of Medicine·N R FaridJ C Bear
Oct 1, 1990·Veterinary Immunology and Immunopathology·S R SijtsmaA J van der Zijpp
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H C ErtlR W Finberg
Jan 1, 1986·Avian Pathology : Journal of the W.V.P.A·M J Cannon, P H Russell
Apr 1, 1982·The Journal of Experimental Medicine·A J InfanteC G Fathman
Mar 1, 1983·The Journal of Experimental Medicine·D W LanckiF W Fitch
Apr 1, 1986·Immunological Reviews·R W Finberg, H C Ertl
Oct 1, 1987·European Journal of Immunology·R Bösing-Schneider, H C Selinka
Apr 1, 1982·European Journal of Immunology·R Grützmann, G J Hämmerling
Oct 15, 1983·International Journal of Cancer. Journal International Du Cancer·H BinzH Wigzell

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