PMID: 6160611Jan 1, 1980Paper

Idiotypic lymphocytes in the rabbit: occurrence and nature of idiotypic lymphocytes in normal and hyperimmunized rabbits

Scandinavian Journal of Immunology
E J BastR E Ballieux

Abstract

Rabbits were hyperimmunized with Micrococcus Pysodeicticus, leading to homogeneous antibody responses. Peripheral blood lymphocytes were taken from the rabbits before and monthly (during 3 months) after the start of the immunization. The cells were stored frozen. Lymphocytes were tested with anti-idiotypic conjugates for the presence of surface idiotypic structures. The nature of the idiotype-positive cells was determined with respect to the presence of IgM or T-cell antigenic determinants on their surface. A sharp rise and fall in the percentage of idiotypic lymphocytes was found, ranging between 1/40,000 and 1/1,000. Initially almost all idiotypic lymphocytes were IgM-positive. In the blood taken 2 months after the start of the immunization 20% of the idiotypic cells belonged to the T-cell population and 10% were negative for both IgM and T-cell antigenic determinants.

References

Jan 1, 1977·Immunological Reviews·P A CazenaveC Bona
Jan 1, 1977·Immunological Reviews·H RamseierJ Lindenmann
Dec 1, 1977·European Journal of Immunology·J L Preud'hommeM Seligmann
Jan 1, 1978·Advances in Immunology·K Eichmann
Dec 1, 1979·European Journal of Immunology·B J BastR E Ballieux
Sep 19, 1975·Science·E S Vitetta, J W Uhr
Jul 1, 1976·European Journal of Immunology·K OkumuraL A Herzenberg
May 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·J V WellsD Givol
Nov 1, 1973·The Journal of Experimental Medicine·D G Braun, A S Kelus
Jan 1, 1970·The Journal of Experimental Medicine·J E HopperA Nisonoff

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