IDL composition and angiographically determined progression of atherosclerotic lesions during simvastatin therapy

Arteriosclerosis, Thrombosis, and Vascular Biology
W H SutherlandH L Walker

Abstract

Some patients with coronary artery disease experience continued progression of one or more coronary lesions despite treatment with drugs that inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and markedly lower plasma cholesterol levels. We examined relationships between the progression of coronary artery lesions and plasma lipoproteins, in particular intermediate density lipoprotein (IDL) and its composition, in 38 patients with coronary artery disease who had been treated with simvastatin for 2 years. Patients were given lipid-lowering dietary advice; 3 months later they were started on simvastatin therapy (10 mg/d) for 1 month, and after review of their plasma cholesterol levels, the dose was increased to 20 mg/d and later to 40 mg/d if the target level of plasma cholesterol had not been attained. Progression of lesions was determined by serial quantitative coronary angiography (variability of 5.5%) and was defined as an increase in percent diameter stenosis (%S)> or =10%; regression was defined as a decrease in %S > or =10%. The proportions of cholesteryl esters (CEs) and free cholesterol decreased significantly (P<.001), and proportions of protein and triglycerides increased significantly (P<.001) in IDL dur...Continue Reading

References

Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Dec 19, 1990·JAMA : the Journal of the American Medical Association·J P KaneR J Havel
May 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·G M KostnerP Pichler
Dec 1, 1986·The American Journal of Clinical Nutrition·P T WilliamsP D Wood
Jan 1, 1986·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T A MuslinerR M Krauss
Apr 1, 1983·Metabolism: Clinical and Experimental·P J Nestel, T Billington
Apr 1, 1993·Circulation·D WatersJ Lespérance

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.