Ieodoglucomides A and B from a marine-derived bacterium Bacillus licheniformis

Organic Letters
Fakir Shahidullah TareqHee Jae Shin

Abstract

Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey's and Mosher's methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI(50) values of 25.18 and 17.78 μg/mL, respectively.

References

Jul 4, 1990·Journal of the National Cancer Institute·P SkehanM R Boyd
Jan 1, 1989·Annual Review of Biochemistry·K A Karlsson
Jun 9, 1995·Journal of Medicinal Chemistry·M MoritaH Fukushima
Jan 1, 1994·Applied and Environmental Microbiology·S C LinG Georgiou
Nov 22, 1995·Carbohydrate Research·Z ZhangK Nakao
Jan 26, 2002·Science·D N Thomas, G S Dieckmann
Apr 4, 2003·Chemical & Pharmaceutical Bulletin·Masashi TsudaJun'ichi Kobayashi
Jul 5, 2003·Bioscience, Biotechnology, and Biochemistry·Jiraporn ThaniyavarnShigenori Kanaya
Nov 19, 2003·Natural Product Reports·R X Tan, J H Chen
Nov 25, 2004·Phytochemistry·Moyosoluwa OluwatuyiSimon Gibbons
Sep 13, 2007·Journal of Natural Products·Tayyab A MansoorJee H Jung
Aug 7, 2008·Journal of Natural Products·Giovanni AppendinoM Mukhlesur Rahman

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Citations

Aug 15, 2013·Marine Drugs·Muhammad Abdul Mojid MondolMohammad Tofazzal Islam
Dec 7, 2017·Frontiers in Pharmacology·Shivankar AgrawalSunil K Deshmukh
Apr 14, 2016·Natural Product Reports·Mingzi M ZhangHuimin Zhao
Jan 27, 2015·Natural Product Reports·John W BluntMichèle R Prinsep
Aug 24, 2018·Marine Drugs·Iván Cheng-Sánchez, Francisco Sarabia
Jan 7, 2014·Natural Product Reports·John W BluntMichèle R Prinsep
Feb 26, 2019·Microbiology Resource Announcements·Mugesh Subramanian, Murugan Maruthamuthu
May 2, 2018·Pharmaceutics·Tomasz M Karpiński, Artur Adamczak
Jan 31, 2020·Frontiers in Chemistry·Kunlong LiHuaming Tao
Jan 14, 2021·Archives of Microbiology·Aneetta Francis, Kajal Chakraborty
Apr 2, 2021·Frontiers in Microbiology·Jinpu YangFeng Ji
Apr 10, 2013·The Journal of Organic Chemistry·Chada Raji ReddyKothakonda Rajendra Prasad

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