PMID: 8946461Nov 1, 1996Paper

If Dr. Bazett had had a computer

Pacing and Clinical Electrophysiology : PACE
M Malik

Abstract

The original data of 109 pairs of RR and QT intervals published by Dr. Bazett in 1920 were subjected to a computerized optimization of the QT/RR relationship. Four generic formulae expressing QT interval as alpha + beta RR mu, alpha + beta e mu RR, alpha + beta e(1/mu RR), and alpha + beta ln mu(10 x RR) were used, and for each formula, optimum combinations parameters alpha, beta, and mu were established that lead to minimum differences between the actual QT interval intervals and values predicted by the model. The results show that independent of the generic formula used, parameters of the model can be selected that provide a close fit of the measured values. Compared to the optimum models obtained in this way, the optimum fit of the Bazett model, QT = beta RR1/2, overestimates the QT intervals for slow heart rates. In addition to demonstrating the procedure of obtaining an optimum QT/RR model for a given data set, the study suggests that critical understanding of the principal limitations of every QT/RR model is more important than its mathematical form.

References

Aug 26, 1993·The American Journal of Cardiology·C Funck-Brentano, P Jaillon
Nov 1, 1996·Pacing and Clinical Electrophysiology : PACE·M Malik, A J Camm

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Citations

Aug 21, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Radu NegoesAlin Achim
Jul 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Ramakrishna Mukkamala, Da Xu
Feb 20, 2007·Srpski arhiv za celokupno lekarstvo·Branislav MilovanovićSlavica Nikolić
May 17, 2007·Srpski arhiv za celokupno lekarstvo·Branislav MilovanovićTijana Mirjanić
Apr 29, 2010·Srpski arhiv za celokupno lekarstvo·Branislav MilovanovićMirjana Krotin
Apr 25, 2007·Scandinavian Cardiovascular Journal : SCJ·Willy AasebøKnut Stavem
Jun 23, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·M Malik, A J Camm
Mar 8, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Daniel M BeyerbachDouglas P Zipes
Apr 26, 2014·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Divyang PatelJan Němec
Sep 14, 2010·IEEE Transactions on Bio-medical Engineering·Gokul SwamyRamakrishna Mukkamala
Nov 14, 2006·Journal of Pharmacological and Toxicological Methods·Henry H HolzgrefeStephen K Durham
Oct 29, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·A John Camm
Sep 24, 2013·Acta Physiologica Hungarica·Š Kujaník, J Petrovičová
Oct 1, 2003·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Jan BrouwerArthur A M Wilde
Nov 25, 2019·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Katerina Hnatkova, Marek Malik
Sep 29, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Gokul SwamyRamakrishna Mukkamala

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