If you don't look, you won't see: intravital multiphoton imaging of primary and metastatic breast cancer.

Journal of Mammary Gland Biology and Neoplasia
Laura BonapaceMohamed Bentires-Alj

Abstract

A fundamental hallmark of cancer is progression to metastasis and the growth of breast cancer metastases in lung, bone, liver and/or brain causes fatal complications. Unfortunately, the cellular and biochemical mechanisms of the metastatic process remain ill-defined. Recent application of intravital multiphoton microscopy (MP-IVM) to image fluorescently labeled cells in mouse models of cancer has allowed dynamic observation of this multi-step process at the cellular and subcellular levels. In this article, we discuss the use of MP-IVM in studies of breast cancer metastasis, as well as surgical techniques for exposing tumors prior to imaging. We also describe a versatile multiphoton microscope for imaging tumor-stroma interactions.

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Citations

Jun 26, 2012·Journal of Mammary Gland Biology and Neoplasia·Mohamed Bentires-Alj, Teresa L Wood
Nov 8, 2003·Social Science & Medicine·Tim Ensor
Feb 3, 2015·ACS Chemical Biology·Krysten A JonesJennifer A Prescher
Feb 3, 2018·Journal of Medical Imaging·Michael A PinkertKevin W Eliceiri
Mar 15, 2019·Nature·Milan M S ObradovićMohamed Bentires-Alj
Feb 27, 2020·Trends in Cancer·Peng SiBryan Ronain Smith

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