Ifenprodil rapidly ameliorates depressive-like behaviors, activates mTOR signaling and modulates proinflammatory cytokines in the hippocampus of CUMS rats

Psychopharmacology
Yamin YaoYiru Fang

Abstract

The rapid-onset and long-lasting antidepressant properties of ketamine have prompted investigations into a variety of agents that target N-methyl-D-aspartate receptors (NMDARs) for the treatment of major depressive disorder (MDD). According to the literature, ifenprodil (a GluN2B-containing NMDAR antagonist) can potentiate the antidepressant-like effects of certain antidepressant drugs in mice. Here, we report that a single injection of ifenprodil (3 mg/kg, intraperitoneally (i.p.)) was sufficient to provoke rapid antidepressant-like effects in chronic unpredictable mild stress (CUMS) rats. Moreover, ifenprodil activated mTOR signaling and reversed the CUMS-induced elevation of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in the hippocampus after acute administration. Unfortunately, in our study, ifenprodil had no influence on corticosterone levels in the plasma. Our data indicate that ifenprodil per se might exert antidepressant-like effects by modulating neuroplasticity and inflammatory processes rather than the typical hormonal factors affected by stressors. To explore the potential rapid antidepressant-like effects and mechanisms of ifenprodil, a GluN2B subunit-selective NMDAR antagonist...Continue Reading

References

Jan 6, 2001·Neuron·M Fava, K S Kendler
Mar 5, 2003·Hormones and Behavior·Karen J ParkerDavid M Lyons
Dec 1, 2005·Trends in Immunology·Charles L RaisonAndrew H Miller
Dec 7, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin J HallAnirvan Ghosh
Jan 19, 2008·Trends in Neurosciences·Benjamin J Hall, Anirvan Ghosh
May 2, 2008·British Journal of Pharmacology·S P H AlexanderJ A Peters
Jul 22, 2008·Biological Psychiatry·Mounira Banasr, Ronald S Duman
May 15, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lêda S B GarciaJoão Quevedo
May 21, 2009·Nature Reviews. Neuroscience·Adriana FederDennis S Charney
May 27, 2009·Nature Reviews. Neuroscience·Yvonne M Ulrich-Lai, James P Herman
Jun 2, 2009·Brain Research Reviews·Kenji Hashimoto
Feb 6, 2010·British Journal of Pharmacology·A Tanti, C Belzung
Sep 16, 2010·Nature Reviews. Neuroscience·Giles E Hardingham, Hilmar Bading
Mar 29, 2011·Stress : the International Journal on the Biology of Stress·Eneritz Gómez-LázaroLarraitz Garmendia
Sep 13, 2011·Neuropharmacology·Ronald S DumanGeorge Aghajanian
Nov 2, 2011·Brain, Behavior, and Immunity·Matthew G FrankSteven F Maier
Sep 11, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lin ZhangShu Yan Yu
Oct 23, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Barbara Sperner-UnterwegerDietmar Fuchs
Apr 9, 2013·Psychopharmacology·Kenji HashimotoAkira Kishimoto
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maria TalantovaStuart A Lipton
Apr 20, 2014·Neuron·Matthew P Parsons, Lynn A Raymond
May 14, 2014·Expert Opinion on Investigational Drugs·Bartłomiej PochwatGabriel Nowak
May 30, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Laura Jiménez-SánchezAlbert Adell
Jul 30, 2014·Neurochemical Research·Mahamaya BhattacharyyaPeter Frederikse
Oct 2, 2014·The Journal of Clinical Psychiatry·Le-Ben WanJames W Murrough
Oct 22, 2014·Proceedings of the National Academy of Sciences of the United States of America·Georgia E HodesScott J Russo
Dec 3, 2014·Pharmacological Reports : PR·Ewa PoleszakPiotr Wlaź
Apr 8, 2015·Human Psychopharmacology·Caoimhe M Coyle, Keith R Laws
Jan 12, 2016·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Matthew D CooperRoger S McIntyre
Feb 3, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Robert A SchoeversRudie Kortekaas
Feb 9, 2016·Drug Discovery Today·Danielle M GerhardRonald S Duman
Feb 24, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Harris A EyreBernhard T Baune
Apr 12, 2016·Depression and Anxiety·Chadi G AbdallahJohn H Krystal

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

ImageJ
GraphPad Prism
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.