IFI44L is a novel tumor suppressor in human hepatocellular carcinoma affecting cancer stemness, metastasis, and drug resistance via regulating met/Src signaling pathway

BMC Cancer
Wei-Chieh HuangPei-Yi Chu

Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The disease recurrent rate is relatively high resulted in poor 5-year survival in advanced HCC. Cancer stem cells (CSCs) have been considered to be one of the main mechanisms for chemoresistance, metastasis, and recurrent disease. Interferon-induced protein 44-like (IFI44L) gene is a type I interferon-stimulated gene (ISG) and belongs to the IFI44 family. Previous reports indicated antiviral activity against HCV in IFI44L, however, its precise role and function in HCC has not been unveiled. To explore the characteristics of hepatic CSCs, we successfully enriched hepatic cancer stem-like cells from three established liver cancer cell lines (Hep3B, HepG2, and PLC lines). Parental Hep3B and HepG2 cells and their sphere cells were treated with doxorubicin for 48 h and cell viability was measured by MTT assay. HCC tissue blocks from 217 patients were sampled for tissue microarray (TMA). Follow-up information and histopathological and clinical data including age, gender, tumor grade, advanced stages, HBV, HCV, tumor number, tumor size, relapse-free survival, and overall survival were obtained from the cancer registry and medical charts. The ...Continue Reading

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Citations

Jun 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emmanouil PapasavvasLuis J Montaner
Aug 23, 2019·Molecular and Cellular Biochemistry·Ximeng JiSheng Yi
Apr 25, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ju-Yong WangShi-Bao Lu
Jul 20, 2019·BioMed Research International·Yen-Bin HsuMing-Ying Lan
Mar 7, 2020·Molecular Therapy Oncolytics·Layal MassaraMyriam Capone
Dec 23, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaoqiang SiShuyi Chenge
Apr 17, 2021·Scientific Reports·Isabella BattenNollaig M Bourke
Jul 3, 2021·Current Oncology·Ritu ShresthaAparna Jayachandran

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Datasets Mentioned

BETA
AB000115

Methods Mentioned

BETA
transfection
xenograft

Software Mentioned

ImageJ
SPSS

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