IFI44L promoter methylation as a blood biomarker for systemic lupus erythematosus

Annals of the Rheumatic Diseases
Ming ZhaoQianjin Lu

Abstract

Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease with limited reliable diagnostic biomarkers. We investigated whether gene methylation could meet sensitivity and specificity criteria for a robust biomarker. IFI44L promoter methylation was examined using DNA samples from a discovery set including 377 patients with SLE, 358 healthy controls (HCs) and 353 patients with rheumatoid arthritis (RA). Two independent sets including 1144 patients with SLE, 1350 HCs, 429 patients with RA and 199 patients with primary Sjögren's syndrome (pSS) were used for validation. Significant hypomethylation of two CpG sites within IFI44L promoter, Site1 (Chr1: 79 085 222) and Site2 (Chr1: 79 085 250; cg06872964), was identified in patients with SLE compared with HCs, patients with RA and patients with pSS. In a comparison between patients with SLE and HCs included in the first validation cohort, Site1 methylation had a sensitivity of 93.6% and a specificity of 96.8% at a cut-off methylation level of 75.5% and Site2 methylation had a sensitivity of 94.1% and a specificity of 98.2% at a cut-off methylation level of 25.5%. The IFI44L promoter methylation marker was also validated in an European-derived cohort. In addition, the met...Continue Reading

References

Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Jul 27, 2000·Journal of Clinical Pathology·W Egner
May 15, 2002·Annals of the Rheumatic Diseases·C VitaliUNKNOWN European Study Group on Classification Criteria for Sjögren's Syndrome
Jul 13, 2002·Arthritis and Rheumatism·Qianjin LuBruce Richardson
Sep 5, 2002·Arthritis and Rheumatism·Daniel H SolomonUNKNOWN American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emily C BaechlerTimothy W Behrens
Sep 11, 2003·Autoimmunity Reviews·Gary W Zieve, Permanan R Khusial
Feb 27, 2004·Autoimmunity·Carmen Gota, Leonard Calabrese
Mar 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariana J KaplanBruce Richardson
Dec 8, 2004·Lupus·M A DooleyE M Ginzler
May 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qianjin LuBruce C Richardson
Jun 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esteban BallestarBruce C Richardson
Aug 22, 2006·Scandinavian Journal of Immunology·B T Kurien, R H Scofield
Sep 15, 2007·Nature Protocols·Jörg Tost, Ivo G Gut
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Qianjin LuBruce Richardson
Nov 10, 2010·Nature Reviews. Rheumatology·Yun Deng, Betty P Tsao
Mar 26, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Matlock A JeffriesAmr H Sawalha
Jun 28, 2011·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Wako Yumura
Sep 20, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Timothy B Niewold
Dec 2, 2011·The New England Journal of Medicine·George C Tsokos
May 5, 2012·Arthritis Care & Research·Bevra H HahnUNKNOWN American College of Rheumatology
Sep 5, 2012·Nature Reviews. Genetics·Holger Heyn, Manel Esteller
Oct 23, 2012·International Journal of Rheumatic Diseases·Ronald HerbstYihong Yao
Dec 24, 2013·Nature Reviews. Immunology·Lionel B Ivashkiv, Laura T Donlin
Jan 28, 2014·Journal of Autoimmunity·Cong YuChristopher Chang

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Citations

Oct 22, 2016·International Immunopharmacology·Shuaihantian LuoQianjin Lu
Oct 26, 2016·Journal of Autoimmunity·Hai LongQianjin Lu
Nov 2, 2016·Clinical and Experimental Immunology·S H ChenB Sun
Nov 9, 2016·Journal of the American Society of Nephrology : JASN·Britta E JonesDominic J Ciavatta
Feb 19, 2017·Autoimmunity Reviews·Haijing WuQianjin Lu
Nov 26, 2016·Epigenomics·Christian M HedrichGeorge C Tsokos
Apr 1, 2017·Current Opinion in Rheumatology·Zijun WangQianjin Lu
Aug 5, 2017·Biomarkers in Medicine·Jinrong ZengQianjin Lu
Oct 10, 2018·Annals of the Rheumatic Diseases·Hong ZhuShu-Feng Lei
Dec 13, 2018·Current Opinion in Rheumatology·Eva SchrezenmeierThomas Dörner
Feb 27, 2019·Current Rheumatology Reports·Marta E Alarcón-Riquelme
Sep 15, 2017·Nature Reviews. Rheumatology·Esteban Ballestar, Tianlu Li
Jan 25, 2018·Nature Reviews. Rheumatology·Guillermo BarturenMarta E Alarcón-Riquelme
Feb 6, 2020·Autoimmunity·Carolina HurtadoGloria Vásquez
Dec 2, 2017·Current Opinion in Rheumatology·Deepa Hammaker, Gary S Firestein
Aug 5, 2020·Expert Review of Clinical Immunology·Wenhui ZhouQianjin Lu
Mar 23, 2017·Epigenomics·Amr H Sawalha
May 7, 2019·Frontiers in Immunology·Qiancheng DengRong Xiao
Dec 19, 2019·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Mansour KarimifarRasoul Salehi
Aug 28, 2020·Frontiers in Genetics·Beenish RahatJyotdeep Kaur
Jul 1, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Paula Quintero-Ronderos, Paul Laissue
May 2, 2019·Frontiers in Immunology·Chary Lopez-PedreraCarlos Perez-Sanchez
May 14, 2020·Current Rheumatology Reports·Qianwen LiQianjin Lu
Aug 8, 2020·Nature Reviews. Rheumatology·Esteban BallestarQianjin Lu
Jul 13, 2020·Current Rheumatology Reports·Tayfun Hilmi AkbabaSeza Ozen
Aug 23, 2017·Expert Opinion on Therapeutic Targets·Heng LiJianping Zuo
Nov 27, 2019·International Journal of Molecular Sciences·Elkin Navarro QuirozRoberto Navarro Quiroz
Aug 31, 2019·Nature Communications·Cristina M LanataLindsey A Criswell
Jul 6, 2018·Cellular and Molecular Life Sciences : CMLS·Zijun WangQianjin Lu
Apr 25, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ju-Yong WangShi-Bao Lu
Jul 3, 2020·Clinical Rheumatology·Matteo VecellioCarlo Selmi
Aug 9, 2017·Clinical Epigenetics·Zijun WangQianjin Lu
Oct 16, 2019·Frontiers in Immunology·Haijing WuQianjin Lu

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