IFITM3 rs12252 T>C polymorphism is associated with the risk of severe influenza: a meta-analysis

Epidemiology and Infection
Y XuanP M Wei

Abstract

The interferon-inducible transmembrane protein 3 (IFITM3), as one of the key genes involved in the interferon pathway, is critical for defending the host against influenza virus, and the rs12252 T>C variant in IFITM3 might be associated with susceptibility to severe influenza. Owing to contradictory and inconclusive results, we performed a meta-analysis to assess the association between rs12252 T>C polymorphism and severe influenza risk. A comprehensive literature search up to 1 August 2014 was conducted in EMBASE, Pubmed, Web of Science, VIP, Wanfang and CNKI databases. Four eligible studies with a total of 445 influenza patients and 3396 controls were included in this meta-analysis. Overall, our results demonstrated a significant association between the IFITM3 rs12252 T>C polymorphism and influenza risk [C vs. T: odds ratio (OR) 1·68, 95% confidence interval (CI) 1·32-2·13; CC vs. CT+TT: OR 2·38, 95% CI 1·52-3·73; CC+CT vs. TT: OR 1·62, 95% CI 1·18-2·22]. Stratification by ethnicity indicated that the variant C allele was associated with an 88% increased risk of influenza in Asians (C vs. T: OR 1·88, 95% CI 1·34-2·62). Moreover, subjects carrying the variant C allele had an increased risk of developing severe illness upon inf...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Feb 10, 2006·JAMA : the Journal of the American Medical Association·Jaime L PetersLesley Rushton
Nov 21, 2008·Nature·Jeremy GinsbergLarry Brilliant
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
May 7, 2010·The New England Journal of Medicine·Edgar BautistaKarl G Nicholson
Mar 23, 2012·PloS One·Peter HorbyJ Kenneth Baillie
Mar 27, 2012·Nature·Aaron R EverittPaul Kellam
Jun 14, 2012·PloS One·Tillmann WeberDusan Bartsch
Jul 6, 2012·Statistics in Medicine·Dan JacksonRichard D Riley
Apr 13, 2013·The New England Journal of Medicine·Rongbao GaoYuelong Shu
May 24, 2013·The New England Journal of Medicine·Hai-Nv GaoLan-Juan Li
Sep 3, 2013·The Journal of Infectious Diseases·Tara C MillsAdrian V S Hill
Sep 27, 2013·Influenza and Other Respiratory Viruses·Peter HorbyJohn Kenneth Baillie
Oct 29, 2013·Scientific Reports·J C F M DortmansC A M de Haan
Dec 25, 2013·Proceedings of the National Academy of Sciences of the United States of America·Zhongfang WangJianqing Xu
Apr 4, 2014·The New England Journal of Medicine·Harvey V Fineberg
Jul 6, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·D WangY Shu
Dec 3, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Matloob Husain

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Citations

Oct 17, 2015·Viruses·Alessandro BoianelliEsteban A Hernandez-Vargas
Mar 4, 2017·PloS One·Michael WinklerStefan Pöhlmann
Jan 22, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Kirsten C VerheinSteven R Kleeberger
Aug 25, 2017·EMBO Reports·Nicholas M ChesarinoJacob S Yount
Apr 24, 2020·Emerging Microbes & Infections·Na LeiYuelong Shu
Aug 15, 2019·Veterinary Research Communications·Yong-Chan KimByung-Hoon Jeong
Jan 9, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anshu P Gounder, Adrianus C M Boon
Apr 4, 2021·Viruses·Joe McKellarCaroline Goujon

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