IFN-γ induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense

Mucosal Immunology
Shanshan CaiSamithamby Jeyaseelan

Abstract

The role of interleukin-17A (IL-17A) in host defense against Legionella pneumophila remains elusive. To address this issue, we used Il17a(-/-), Il17f(-/-), and Il17a/Il17f(-/-) mice on a C57Bl/6 (non-permissive) background and IL-17 neutralizing Abs in mice on an A/J (permissive) background. Higher bacterial (L. pneumophila) counts in the lung and blood along with reduced neutrophil recruitment were detected in Il17a(-/-), but not Il17f(-/-), mice. We found that neutrophils produce IL-17A homodimer (IL-17A) during L. pneumophila infection, and hematopoietic cell-derived IL-17A is known to be important for bacterial clearance. Thus, intratracheal administration of wild-type neutrophils or recombinant IL-17A restored bacterial clearance and neutrophil recruitment in Il17a(-/-) mice. Furthermore, neutrophil-depleted Rag2(-/-) and Rag2/Il-2rγ(-/-) mice exhibited increased bacterial burden, reduced neutrophil influx and IL-17A production in the lung. Recombinant IFN-γ administration in Il17a(-/-) mice augmented bacterial elimination, whereas IL-17A administration in Ifnγ(-/-) mice did not augment bacterial clearance. IFN-γ is produced by T cells, but not neutrophils or macrophages, suggesting that neutrophil-derived IL-17A induces I...Continue Reading

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S D WolpeA Cerami
Apr 19, 2000·Antimicrobial Agents and Chemotherapy·J K BrielandR S Hare
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K TatedaT J Standiford
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·G Matute-BelloT R Martin
Oct 10, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·T StarnesR Hromas
Dec 20, 2002·Seminars in Pediatric Infectious Diseases·Herman FriedmanThomas W Klein
Mar 30, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shawn J SkerrettChristopher B Wilson
Jun 17, 2004·Molecular and Cellular Biology·Oliver UttingAndré Veillette
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giovanna SchiavoniEnrico Proietti
Jan 11, 2005·The European Respiratory Journal·A LindénG P Anderson
Mar 22, 2005·American Journal of Respiratory Cell and Molecular Biology·Samithamby JeyaseelanG Scott Worthen
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicolas NoulinIsabelle Couillin
Jan 13, 2006·PLoS Medicine·Joseph P Mizgerd
May 3, 2006·Diagnostic Microbiology and Infectious Disease·Ma Teresa Agulló-OrtuñoJosé A Noguera-Velasco
Sep 5, 2006·The Journal of Infection·Fabio Di StefanoMario Di Gioacchino
Sep 15, 2006·The European Respiratory Journal·B SchmeckS Hippenstiel
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li LiMark D Okusa
Nov 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Spencer C LiangLynette A Fouser
Jan 15, 2008·American Journal of Respiratory Cell and Molecular Biology·Lee J QuintonJoseph P Mizgerd
Apr 16, 2008·The Journal of Experimental Medicine·Xuexian O YangChen Dong
Jul 2, 2008·The Journal of Experimental Medicine·Cindy S MaMatthew C Cook
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jill F WrightBeatriz M Carreno
Nov 8, 2008·American Journal of Respiratory Cell and Molecular Biology·Shanshan CaiSamithamby Jeyaseelan
Jan 24, 2009·Immunological Reviews·Yoichiro IwakuraHarumichi Ishigame
Sep 2, 2009·The Journal of Biological Chemistry·Courtney R PlumleeChristian Schindler
Oct 20, 2009·Nature Immunology·Lauren K ElyK Christopher Garcia
Nov 11, 2009·Infection and Immunity·Ariana Peck, Elizabeth D Mellins
Jun 15, 2010·Current Opinion in HIV and AIDS·Lokesh Guglani, Shabaana A Khader
Oct 13, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shanshan CaiSamithamby Jeyaseelan
Nov 16, 2010·Cytokine & Growth Factor Reviews·Joseph M ReynoldsChen Dong
Nov 16, 2010·Cytokine & Growth Factor Reviews·Shabaana A Khader
Nov 26, 2010·Cytokine & Growth Factor Reviews·Jay K Kolls, Shabaana A Khader
Dec 7, 2010·Cellular Signalling·Seon Hee Chang, Chen Dong
Dec 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jr-Shiuan LinStephen T Smiley
Feb 22, 2011·Protein & Cell·Xiaoping ZhangHong Tang
Feb 26, 2011·Immunity·Yoichiro IwakuraSusumu Nakae
Dec 7, 2011·Infection and Immunity·Yoshifumi KimizukaKeizo Yamaguchi
Mar 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sanjay BatraSamithamby Jeyaseelan
May 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shanshan CaiSamithamby Jeyaseelan
Jan 7, 2014·Archivos de bronconeumología·Jordi AlmirallSalvador Bello

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Citations

Jul 12, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marika OrlovMark M Wurfel
May 18, 2018·European Journal of Clinical Investigation·Nicola TamassiaMarco A Cassatella
Oct 30, 2016·The British Journal of Dermatology·R SpeeckaertN van Geel
Nov 8, 2017·Mycoses·Alexandre Giannecchini RomagnoloLuciane Alarcão Dias-Melicio
May 17, 2018·Physiological Reviews·Lee J QuintonJoseph P Mizgerd
Aug 15, 2017·PloS One·Marika OrlovCarmen Mikacenic
Jul 18, 2017·F1000Research·Shibali Das, Shabaana Khader
Jul 29, 2019·Journal of Molecular Biology·Xin Liu, Sunny Shin
Jun 3, 2021·MBio·Christopher T D PriceYousef Abu Kwaik

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