IFN-λ inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production

Antiviral Research
Ren-Rong TianJian-Hua Wang

Abstract

The lambda interferons (IL-28a, 28b, and IL-29) inhibit the replication of many viruses, but their role in the inhibition of HIV-1 infection remains unclear. During this study, we monitored IL-29 production in HIV-1 infected individuals and analyzed the in vitro and in vivo inhibition of HIV-1 production. Prior treatment with IL-28a or IL-29 induced an antiviral state in cultured primary T-cells, which suppressed HIV-1 integration and post-transcriptional events. The antiviral factors MxA, OAS, and PKR were up-regulated. In HIV-1 infected patients, IL-29 level was increased along with the depletion of CD4⁺ T-cells in peripheral blood, while the elevated IL-29 did not show a significantly negative correlation with viral load. Further analysis of HIV-1 infected individuals showed that IL-29 was positively correlated with IFN-β and anti-inflammatory cytokine IL-10, and was negatively correlated with IFN-γ, which might suggest that IFN-λ participates in modulating antiviral immune responses during HIV-1 infection in vivo. Together, although IFN-λ impeded HIV-1 infection of T-cells in vitro, IFN-λ showed only limited in vivo repression of viral production. The modulation of IFN-λ on inflammatory factors might be worthy for further c...Continue Reading

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Citations

Jan 19, 2018·Journal of Leukocyte Biology·Dominik Hotter, Frank Kirchhoff
Jan 1, 2016·Journal of Virology·Ai-Ping JiangJian-Hua Wang
Mar 13, 2014·American Journal of Reproductive Immunology : AJRI·Victor H FerreiraCharu Kaushic
Aug 25, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ming DaiWen-Zhe Ho
Nov 30, 2018·Protein Engineering, Design & Selection : PEDS·Wu-Mei YuanLi-Shu Zheng
Mar 23, 2017·Frontiers in Immunology·Xu WangWen-Zhe Ho
Dec 23, 2017·Frontiers in Immunology·Emily A HemannRam Savan
Mar 16, 2017·Frontiers in Immunology·Mohammedyaseen Syedbasha, Adrian Egli
Jun 4, 2019·Frontiers in Immunology·Jake William RhodesStuart Grant Turville
Aug 23, 2020·International Journal of Molecular Sciences·Antonio Pérez-PérezVíctor Sánchez-Margalet

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