IFN-γ-primed human bone marrow mesenchymal stem cells induce tumor cell apoptosis in vitro via tumor necrosis factor-related apoptosis-inducing ligand

The International Journal of Biochemistry & Cell Biology
Jingchun DuAndy Peng Xiang

Abstract

Human mesenchymal stem cells hold promise as gene therapy vectors for delivery of various genes to solid tumors for either therapeutic or tumor-tracing purposes. However, whether Mesenchymal stem cells support or inhibit tumor growth remains unknown. Herein, we first observed that mesenchymal stem cells primed with IFN-γ selectively induced the death of tumor cell lines, but not normal cells. We further identified that IFN-γ-primed mesenchymal stem cells expressed tumor necrosis factor-related apoptosis-inducing ligand. Tumor-suppressive effect of IFN-γ-primed mesenchymal stem cells could be blocked by activity neutralization or expression reduction of tumor necrosis factor-related apoptosis-inducing ligand. Moreover, mesenchymal stem cells mediated apoptosis of tumor cells by activating caspase-3 in such cells, via a mechanism involving tumor necrosis factor-related apoptosis-inducing ligand. However, when IFN-γ-primed or non-primed mesenchymal stem cells were co-injected into nude mice along with H460 cells, tumor growth was much faster than that of the group receiving only tumor cells (p<0.01) because of the promoting vascularization effect of mesenchymal stem cells, although IFN-γ-primed mesenchymal stem cells also exerted ...Continue Reading

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Citations

Jun 28, 2014·Journal of Immunology Research·Xinyuan YangWu Song
Dec 1, 2015·Immunopharmacology and Immunotoxicology·Hemn MohammadpourSayed Mahmoud Hashemi
Dec 24, 2015·International Journal of Molecular Sciences·Ki-Jong RheeYoung Woo Eom
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Feb 16, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Erin Collins, Gary Gilkeson
Apr 29, 2015·International Immunopharmacology·Marcelo Henrique NapimogaElizabeth Ferreira Martinez
Aug 25, 2020·Stem Cells Translational Medicine·Jennifer SteensDiana Klein
Jul 25, 2019·Cell and Tissue Banking·Mansoureh MirabdollahiHojjat Sadeghi-Aliabadi
Jan 22, 2021·Cellular & Molecular Biology Letters·Wenqing LiangXuerong Chen
Mar 10, 2020·Current Stem Cell Research & Therapy·Milena Kostadinova, Milena Mourdjeva

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