IFN-α/β receptor signaling promotes regulatory T cell development and function under stress conditions

The Journal of Immunology : Official Journal of the American Association of Immunologists
Amina MetidjiEthan M Shevach

Abstract

Type I IFNs are a family of cytokines with antiviral and immunomodulatory properties. Although the antiviral effects of IFNs are well characterized, their immunomodulatory properties are less clear. To specifically address the effects of type I IFNs on T regulatory cells (Tregs), we studied mixed bone marrow chimeras between wild-type and IFN-α/β receptor (IFNAR) knockout (KO) mice, and heterozygous female mice expressing a Treg-specific deletion of the IFNAR. In these two models, IFNAR signaling promotes the development of the Treg lineage in the thymus and their survival in the periphery. IFNAR KO Tregs had a higher expression of the proapoptotic gene Bim and higher frequency of active caspase-positive cells. IFNAR KO Tregs from chimeric mice displayed a more naive phenotype, accompanied by lower levels of CD25 and phosphorylated STAT5. Therefore, in Tregs, IFNAR signaling may directly or indirectly affect phosphorylation of STAT5. In mixed chimeras with Scurfy fetal liver, Tregs derived from IFNAR KO bone marrow were unable to control T effector cell activation and tissue inflammation. Under stress conditions or in a competitive environment, IFNAR signaling may be required to maintain Treg homeostasis and function.

References

Feb 28, 1998·The Journal of Biological Chemistry·S L SchaferP M Pitha
Nov 18, 1998·Cellular and Molecular Life Sciences : CMLS·J DolyG Uze
Dec 22, 1998·The Journal of Experimental Medicine·S SunJ Sprent
Jan 5, 1999·The Journal of Biological Chemistry·E N FishL C Platanias
Jan 27, 1999·Biochemical Genetics·H K JinT Watanabe
Feb 2, 1999·The Journal of Experimental Medicine·P MarrackT Mitchell
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J E DurbinD E Levy
Sep 1, 2001·Clinical Rheumatology·E Passos de SouzaM Santiago
Aug 7, 2003·Biochemical and Biophysical Research Communications·Shahab UddinLeonidas C Platanias
Feb 26, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sarah L PoguePina M Cardarelli
Jun 5, 2004·Clinical Neurology and Neurosurgery·Sasa SegaAlojz Ihan
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie M CurtsingerMatthew F Mescher
May 3, 2005·Nature Reviews. Immunology·Leonidas C Platanias
Sep 1, 2005·The Journal of Experimental Medicine·Ganesh A KolumamKaja Murali-Krishna
Mar 7, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Colin Havenar-DaughtonKaja Murali-Krishna
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Agnes Le BonDavid F Tough
Jul 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucas J ThompsonKaja Murali-Krishna
Aug 26, 2006·Nature Reviews. Immunology·Kenya Honda, Tadatsugu Taniguchi
Sep 19, 2006·Immunity·Daniel B Stetson, Ruslan Medzhitov
Dec 22, 2007·Nature Reviews. Molecular Cell Biology·Richard J Youle, Andreas Strasser
Feb 15, 2011·Arthritis Research & Therapy·Mary K Crow
Feb 16, 2011·Immunology·Jonathan P Huber, J David Farrar
Mar 5, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sandra Hervas-StubbsIgnacio Melero
Jan 10, 2012·Nature Reviews. Immunology·José M González-NavajasEyal Raz
Mar 7, 2012·Immunology and Cell Biology·David F Tough
Jun 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Bailey E FreemanMark K Slifka
Apr 13, 2013·Science·John R TeijaroMichael B A Oldstone
Aug 6, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Abhisake KoleBrian L Kelsall
Nov 13, 2013·The Journal of Clinical Investigation·C Andrew StewartGiorgio Trinchieri
Jan 1, 2014·The Journal of Experimental Medicine·Kate S SmigielDaniel J Campbell
Feb 1, 2014·Nature Reviews. Immunology·Adrian Liston, Daniel H D Gray
Apr 9, 2014·The Journal of Experimental Medicine·Shivani SrivastavaDaniel J Campbell
Aug 6, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shivani SrivastavaDaniel J Campbell
Sep 30, 2014·Nature Immunology·Andrew G LevineAlexander Y Rudensky

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Citations

Mar 24, 2016·Nature Immunology·Johanna PottAna Izcue
Mar 16, 2017·Inflammatory Bowel Diseases·Edward M Giles, Andrew J Stagg
Feb 22, 2017·Cell·Naama Geva-ZatorskyDennis L Kasper
Mar 21, 2018·The Journal of Clinical Investigation·Yawara KawanoIrene M Ghobrial
Feb 7, 2017·F1000Research·David L Owen, Michael A Farrar
Jun 13, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sadiye Amcaoglu RiederEthan M Shevach
Sep 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Duncheng WangMark D Mannie
Jan 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Themis AlissafiVily Panoutsakopoulou
Mar 9, 2018·Frontiers in Immunology·Sudeep Chenna NarendraMattias Magnusson
Jul 31, 2019·Nature Reviews. Genetics·Mona MotwaniKatherine A Fitzgerald
Mar 4, 2017·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Aleš GoropevšekTadej Avčin
Mar 3, 2019·Journal of Neuroinflammation·Qianquan MaRong-Fu Wang
Jun 19, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcos VasquezPedro Berraondo
Dec 11, 2019·The Journal of Experimental Medicine·Hung-Jen ChenMenno P J de Winther
Dec 22, 2020·Frontiers in Immunology·Niccolò BianchiSilvia Monticelli
Dec 3, 2020·Annual Review of Pathology·Giselle M BoukhaledDavid G Brooks
Dec 10, 2020·Nature Machine Intelligence·Anthony CulosNima Aghaeepour
Apr 4, 2021·Cancers·Sarah E FentonLeonidas C Platanias
Jul 31, 2021·Journal of the American Heart Association·Lina LaiZequan Yang
Aug 19, 2021·Cell Death & Disease·Céline BarlierAntonio Del Sol
Sep 11, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Nanna JørgensenThomas Vauvert F Hviid

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