IFN-alpha can both protect against and promote the development of type 1 diabetes

Annals of the New York Academy of Sciences
F Susan Wong, Li Wen

Abstract

Viral infection has been hypothesized to be one of the environmental triggers for the development of type 1 diabetes. Infection induces a large amount of interferon-alpha (IFN-alpha) produced by dendritic cells and other cells. To test the role of IFN-alpha in the development of diabetes, we have used three different experimental approaches in both diabetes-prone and -resistant animal models for type 1 diabetes. Our results suggested that a viral mimic or IFN-alpha can either suppress or promote the development of autoimmune diabetes, depending on the model system. It is likely that IFN-alpha plays a complex role in the etiology of type 1 diabetes.

References

Dec 1, 1989·Journal of Autoimmunity·D V SerrezeE H Leiter
Apr 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Hiroaki MoriyamaGeorge S Eisenbarth
Feb 20, 2003·Diabetes/metabolism Research and Reviews·Hee-Sook Jun, Ji-Won Yoon
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Li WenF Susan Wong
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Danny ZiprisAldo A Rossini

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Citations

Sep 20, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Wilhem LeconetDamien Bresson
Feb 15, 2011·Arthritis Research & Therapy·Mary K Crow
Jun 25, 2009·Expert Opinion on Drug Safety·Laura M BurdickAlly-Khan Somani
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ningwen TaiLi Wen
Jun 27, 2014·Scandinavian Journal of Immunology·M PanarinaR Uibo

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