PMID: 9541578Apr 29, 1998Paper

IFN-gamma-induced TNF-alpha is a prerequisite for in vitro production of nitric oxide generated in murine peritoneal macrophages by IFN-gamma

European Journal of Immunology
D Franková, Z Zidek

Abstract

The effect of IFN-gamma to stimulate formation of nitric oxide (NO) by normal murine peritoneal macrophages (M phi) has been found to be completely dependent on the ability of IFN-gamma to activate secretion of TNF-alpha. The NO-stimulatory effect of IFN-gamma was abolished by anti-TNF-alpha antibodies, the inhibitory intervention of which could be fully reversed by exogenously supplied TNF-alpha. Accordingly, the failure of M phi from C3H/HeJ mice to secrete TNF-alpha upon stimulation with IFN-gamma was associated with their complete incapability to generate NO, unless they were simultaneously treated with IFN-gamma + TNF-alpha. Collectively, the data document that similar to the NO up-regulatory action of other cytokines, the effect of IFN-gamma is not independent, but depends on a synergistic cooperation with the self-produced TNF-alpha. The findings thus indicate that a widespread opinion claiming that IFN-gamma per se is able to stimulate biosynthesis of NO needs revision.

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Citations

Jan 29, 2002·International Journal for Parasitology·Alexander W PfaffWolfgang H Hoffmann
Sep 25, 2002·Life Sciences·Yosuke InagakiZenji Makita
Oct 2, 1998·International Journal of Immunopharmacology·Z ZidekH Tlaskalová-Hogenová
Jan 9, 2001·Transplant Immunology·A W BingamanC P Larsen
Aug 2, 2003·International Immunopharmacology·Carolina Solis-MaldonadoRicardo Gomez-Flores
Mar 18, 2006·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sonja SteppanDelanie J Cassell
Oct 19, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Xiao-Yu LuoXiao-Kang Li
Mar 26, 2003·American Journal of Respiratory Cell and Molecular Biology·Shabbir HussainWilliam J Martin
Sep 22, 2009·Canadian Journal of Microbiology·Cecilia HaroGraciela Agüero
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Virginia Vila-del Sol, Manuel Fresno
Apr 10, 2008·European Journal of Immunology·Shoko KurodaAkira Suzuki
Nov 15, 2006·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Michael SchäfferRichard Viebahn
Oct 9, 2008·Canadian Journal of Physiology and Pharmacology·Hyo-Jin AnSeung-Heon Hong
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y YamaguchiM Ogawa
May 19, 2009·The International Journal of Biochemistry & Cell Biology·Katarina H FrendéusMagnus Abrahamson

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