IFN-gamma/STAT1 acts as a proinflammatory signal in T cell-mediated hepatitis via induction of multiple chemokines and adhesion molecules: a critical role of IRF-1

American Journal of Physiology. Gastrointestinal and Liver Physiology
Barbara JarugaBin Gao

Abstract

We have previously shown that IFN-gamma/STAT1 plays an essential role in concanavalin A (ConA)-induced T cell hepatitis via activation of apoptotic signaling pathways. Here we demonstrate that IFN-gamma/STAT1 also plays a crucial role in leukocyte infiltration into the liver in T cell hepatitis. After injection of ConA, leukocytes were significantly infiltrated into the liver, which was suppressed in IFN-gamma(-/-) and STAT1(-/-) mice. Disruption of the IFN regulatory factor-1 (IRF-1) gene, a downstream target of IFN-gamma/STAT1, abolished ConA-induced liver injury and suppressed leukocyte infiltration into the liver. Additionally, ConA injection induced expression of a wide variety of chemokines and adhesion molecules in the liver. Among them, expression of ICAM-1, VCAM-1, monokine induced by IFN-gamma (Mig), CC chemokine ligand-20, epithelial cell-derived neutrophil-activating peptide (ENA)-78, IFN-inducible T cell-alpha chemoattractant (I-TAC), and IFN-inducible protein-10 (IP-10) was markedly attenuated in IFN-gamma(-/-), STAT1(-/-), and IRF-1(-/-) mice. In primary mouse hepatocytes, Kupffer cells, and endothelial cells, in vitro treatment with IFN-gamma activated STAT1, STAT3, and IRF-1, and induced expression of VCAM-1, I...Continue Reading

References

Dec 1, 1993·The Journal of Allergy and Clinical Immunology·A al-WabelS Raziuddin
Jun 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D VrochidesP Heldin
Oct 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J NapoliG W McCaughan
Apr 20, 1999·Biochemical and Biophysical Research Communications·A KanoY Watanabe
Jul 28, 1999·Seminars in Liver Disease·M J Koziel
Jul 28, 1999·Seminars in Liver Disease·C J McClainD Hill
Nov 18, 2000·The New England Journal of Medicine·H Tilg, A M Diehl
Jan 6, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D WolfG Tiegs
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K StreetzC Trautwein
Oct 5, 2001·Clinical Microbiology Reviews·C E Samuel
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C L Bone-LarsonS L Kunkel
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael A Heneghan, Ian G McFarlane
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Andrea KrögerPeter P Mueller
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Giovanna RomeoElisabetta Affabris
Jun 11, 2002·Gastroenterology·Hubert LouisJacques Devière
Sep 26, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ludger LeifeldUlrich Spengler
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Goichi MatsumotoJosef M Penninger
Dec 11, 2002·Cellular Immunology·Katsumitsu AraiGunther Dennert
Jun 21, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Won-Ho KimBin Gao
Sep 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara JarugaBin Gao
Oct 18, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jaspreet S GujralHartmut Jaeschke
Dec 4, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jürgen SieblerMarkus F Neurath
Dec 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudine S BonderMark G Swain

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Citations

Apr 1, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Noriko TsuruokaHideo Inoue
Jul 31, 2013·Journal of Autoimmunity·Palak J Trivedi, David H Adams
Apr 5, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Lin ChenShu-Sen Zheng
Jan 3, 2006·The Journal of Infectious Diseases·Matthew R JonesJoseph P Mizgerd
Apr 3, 2012·AIDS Research and Human Retroviruses·Linden Ann GreenMatthias Clauss
May 24, 2005·Infection and Immunity·Timur O YarovinskyGary W Hunninghake
Jan 15, 2013·BMC Gastroenterology·Mariam Al-ShamsiAbdul-Kader Souid
Apr 30, 2008·Journal of Leukocyte Biology·Daniel VoskasDaniel J Dumont
May 10, 2011·International Journal of Biological Sciences·Hua WangBin Gao
Jun 4, 2014·Critical Care : the Official Journal of the Critical Care Forum·Daniela S HerzigEdward R Sherwood
Oct 30, 2008·Journal of Immunotoxicology·Stephanie R PacittoMarija Popovic
Dec 18, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Simon C AffordBertus Eksteen
May 23, 2012·Cytokine & Growth Factor Reviews·Rowan F van GolenMichal Heger
Feb 22, 2011·Cytokine & Growth Factor Reviews·Christopher J HorrasKristen A Mitchell
Sep 22, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Soichiro FushimiAkihiro Matsukawa
Dec 4, 2015·Toxicology and Applied Pharmacology·Michaël MaesHartmut Jaeschke
Jan 10, 2009·Journal of Autoimmunity·Dolores B NjokuNoel R Rose
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Pallavi SinghGretchen Darlington
Sep 20, 2008·Journal of Hepatology·Charalambos Gustav AntoniadesDiego Vergani
Oct 27, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Natalia A OsnaTerrence M Donohue
Oct 4, 2007·Annals of the New York Academy of Sciences·Patricia F LalorDavid H Adams
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rui SunBin Gao
May 14, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Alexander R MoschenHerbert Tilg
Jul 24, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daming ZuoXiang-Yang Wang
Feb 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shinya UekiDavid A Geller
Apr 11, 2006·European Journal of Pharmacology·Ru ZhouJian-Ping Zuo
Sep 18, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Chi-Li ChungLi-Ming Lien

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