IFNγ-Inducible Chemokines Decrease upon Selenomethionine Supplementation in Women with Euthyroid Autoimmune Thyroiditis: Comparison between Two Doses of Selenomethionine (80 or 160 μg) versus Placebo

European Thyroid Journal
Tania PilliFurio Pacini

Abstract

Several studies have suggested that selenium may influence the natural history of autoimmune thyroiditis (AIT). Recently, IFNγ-inducible chemokines (CXCL-9, -10 and -11) were shown to be elevated in AIT patients. This prospective, randomized, controlled study was conducted to evaluate the effect of two doses of selenomethionine (Semet; 80 or 160 µg/day) versus placebo in euthyroid women with AIT, in terms of reduction of anti-thyroid antibodies, CXCL-9, -10 and -11 and improvement of thyroid echogenicity, over 12 months. Sixty patients, aged 21-65 years, were equally randomized into 3 groups: placebo, 80 µg/day of Semet (80-Semet) or 160 µg/day of Semet (160-Semet). Anti-thyroperoxidase antibody (TPOAb) levels remained unaffected by Semet supplementation; anti-thyroglobulin antibody levels showed a significant reduction in the 160-Semet and the placebo group at 12 months. No significant change in thyroid echogenicity, thyroid volume and quality of life was observed within and between the groups. Subclinical hypothyroidism was diagnosed in 2 patients of the placebo group versus 1 patient in each Semet group. Serum CXCL-9 and -10 were significantly reduced in both Semet groups at 6 and 12 months, while they remained unchanged or ...Continue Reading

Citations

Oct 12, 2018·Journal of Clinical Pharmacy and Therapeutics·Ioannis KyrgiosAssimina Galli-Tsinopoulou
Oct 6, 2018·Diagnostics·Liliana R SantosPaula Soares
Jun 24, 2017·Current Opinion in Endocrinology, Diabetes, and Obesity·Kristian H WintherLaszlo Hegedüs
May 18, 2016·Endocrinology and Metabolism·Wilmar M Wiersinga
Feb 1, 2020·Nature Reviews. Endocrinology·Kristian Hillert WintherLaszlo Hegedüs
Jun 10, 2021·International Journal of Clinical Practice·Jadwiga Kryczyk-KoziołMirosław Bartyzel

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Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

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