IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome.

International Immunopharmacology
Min GuoYongping Jia

Abstract

Pyroptosis is identified as a novel form of inflammatory programmed cell death and has been recently found to be closely related to atherosclerosis (AS). We found that IFN regulatory factor-1(IRF-1) effectively promotes macrophage pyroptosis in patients with acute coronary syndrome (ACS). Subsequent studies have demonstrated that circRNAs are implicated in AS. However, the underlying mechanisms of circRNAs in macrophage pyroptosis remain elusive. We detected the RNA expression of hsa_circ_0002984, hsa_circ_0010283 and hsa_circ_0029589 in human PBMC-derived macrophages from patients with coronary artery disease (CAD). The lentiviral recombinant vector for hsa_circ_0029589 overexpression (pLC5-GFP-circ_0029589) and small interference RNAs targeting hsa_circ_0029589 and METTL3 were constructed. Then, macrophages were transfected with pLC5-GFP-circ_0029589, si-circ_0029589 or si-METTL3 after IRF-1 was overexpressed and to explore the potential mechanism of hsa_circ_0029589 involved in IRF-1 induced macrophage pyroptosis. The relative RNA expression level of hsa_circ_0029589 in macrophages was decreased, whereas the N6-methyladenosine (m6A) level of hsa_circ_0029589 and the expression of m6A methyltransferase METTL3 were validated t...Continue Reading

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Citations

Feb 1, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xiao HeLiming Zhang
Feb 26, 2021·Journal of Cardiovascular Translational Research·Ye-Shi ChenKai Yin
Mar 13, 2021·Frontiers in Cardiovascular Medicine·Soudeh Ghafouri-FardMohammad Taheri
Mar 24, 2021·Journal of Cellular Physiology·Bin HeJianyan Wen
Mar 30, 2021·Frontiers in Immunology·Maorun ZhangZhenqiang Sun
Apr 23, 2021·Journal of Physiology and Biochemistry·Jiaru LiuXiuru Guan
Aug 10, 2021·Frontiers in Cell and Developmental Biology·Jun WuHongyu Sun
Nov 6, 2021·Frontiers in Immunology·Fangzhou TengJingcheng Dong

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