IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection.

BioRxiv : the Preprint Server for Biology
B. RosaDeepak Kaushal

Abstract

The novel virus SARS-CoV-2 has infected more than 14 million people worldwide resulting in the Coronavirus disease 2019 (COVID-19). Limited information on the underlying immune mechanisms that drive disease or protection during COVID-19 severely hamper development of therapeutics and vaccines. Thus, the establishment of relevant animal models that mimic the pathobiology of the disease is urgent. Rhesus macaques infected with SARS-CoV-2 exhibit disease pathobiology similar to human COVID-19, thus serving as a relevant animal model. In the current study, we have characterized the transcriptional signatures induced in the lungs of juvenile and old rhesus macaques following SARS-CoV-2 infection. We show that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are significantly induced in macaque infected lungs, while pathways associated with collagen formation are downregulated. In COVID-19, increasing age is a significant risk factor for poor prognosis and increased mortality. We demonstrate that Type I IFN and Notch signaling pathways are significantly upregulated in lungs of juvenile infected macaques when compared with old infected macaques. These results are corroborated with i...Continue Reading

Citations

Dec 20, 2020·Nature Microbiology·Dhiraj Kumar SinghDeepak Kaushal
Dec 12, 2020·Nature·Erola Pairo-CastineiraJ Kenneth Baillie
May 6, 2021·International Journal of Molecular Sciences·Ashley A StegelmeierKhalil Karimi

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Methods Mentioned

BETA
lavage
RNA-seq
profiler
bronchoalveolar lavage
biopsy
PCA
GTPase

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