IFNgamma-producing, virus-specific CD8+ effector cells acquire the ability to produce IL-10 as a result of entry into the infected lung environment.

Virology
Ellen M PalmerMartha A Alexander-Miller

Abstract

It has become clear that T cells with the potential to negatively regulate the immune response are normal constituents of the immune system. These cells often mediate their effects through the production of immunosuppressive factors. At present our understanding of how these cells are generated is limited. Here we report the presence of a population of IL-10-producing, virus-specific CD8+ T cells in the lungs of mice following acute respiratory infection. These cells were only found at minimal levels in the spleen and draining lymph node; instead they were restricted primarily to the infected lung tissue. A major finding from this study is demonstration that the ability to produce IL-10 can be acquired by IFNgamma-producing effector cells following entry into the infected lung. These studies suggest IL-10 production is the result of further differentiation of an antigen-specific CD8+ T cell that is governed by signals present in infected lung tissue.

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Citations

Jul 22, 2014·Trends in Immunology·Nicole L La Gruta, Stephen J Turner
Mar 10, 2012·Nature Reviews. Immunology·Thomas J BracialeTaeg S Kim
Aug 7, 2013·The Journal of Allergy and Clinical Immunology·Jae-Kwang YooThomas J Braciale
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Feb 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathryn TrandemStanley Perlman
Aug 17, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kayla A WeissSteven M Varga
Mar 21, 2017·Journal of Immunology Research·José M RojasNoemí Sevilla
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Jul 2, 2017·Clinical Science·S Rameeza Allie, Troy D Randall
May 7, 2019·Frontiers in Immunology·Qiancheng DengRong Xiao
Feb 1, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Fabio Marcelo CerbánClaudia Cristina Motran
Aug 17, 2021·Frontiers in Neurology·Shamila D AlipoorIan M Adcock

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