PMID: 8610635Apr 1, 1996Paper

Ifosfamide and cisplatin as neoadjuvant chemotherapy for advanced cervical carcinoma

American Journal of Clinical Oncology
B LeoneM Rabinovich

Abstract

A phase II trial was performed to evaluate the efficacy and toxicity of a combination of cisplatin (CDDP) and ifosfamide (IFX) as neoadjuvant chemotherapy in advanced cervical carcinoma (ACC). Between August 1991 and September 1993, 57 untreated patients with stages IIB to IVA were entered into this study. Median age was 44 years (range, 25 to 74 years). The distribution by stages (International Federation of Gynecology and Obstetrics) was as follows: IIB, 31 patients; IIIB, 21 patients; and IVA, 5 patients. Therapy consisted of IFX 2000 mg/m(2) 1-h i.v. infusion days 1 to 3; mesna 400 mg/m(2) i.v. bolus at hours 0 and 4, and 800 mg p.o. at hour 8; and CDDP 100 mg/m(2) on day 3. Cycles were repeated every 28 days for a total of three courses. Both staging and response assessment were performed by a multidisciplinary team. An objective response was observed in 30 of 56 patients (54%; 95% confidence interval, 41 to 67%). Four patients (7%) had a complete response (CR) and 26(46%) had a partial response (PR). Patients with CR or operable PR underwent surgery, otherwise received definitive radiotherapy. Toxicity was mild to moderate. There were no toxicity related deaths. These results indicate that IFX/CDDP is an active combinatio...Continue Reading

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Citations

Jan 31, 2004·Gynecologic Oncology·Dong Choon ParkSung Eun Namkoong
Nov 16, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliPierluigi Benedetti-Panici
Jul 5, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·C Lopez-GranielA Dueñas-Gonzalez
Jul 24, 2012·Gynecologic Oncology·Roberto AngioliPierluigi Benedetti-Panici
Jun 2, 2009·Vaccine·Rosa De VincenzoGiovanni Scambia
Jun 13, 2006·The Journal of Obstetrics and Gynaecology Research·Hong-Bing CaiHou-Han Yin
May 14, 2005·Critical Reviews in Oncology/hematology·Krystyna Serkies, Jacek Jassem
Jun 19, 2007·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Pascale JollietRoméo Cecchelli
Aug 18, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitchell MorrisDavid H Moore
Jan 5, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pierluigi Benedetti-PaniciFabio Landoni
Sep 15, 2004·Critical Reviews in Oncology/hematology·Rosa TambaroSandro Pignata
Jun 3, 2017·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Rawand SalihiIgnace Vergote
Feb 16, 2005·Current Opinion in Obstetrics & Gynecology·Juan E SardiJuan J Sardi
Aug 6, 2010·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Taisuke MoriJo Kitawaki
Feb 4, 2014·Expert Review of Anticancer Therapy·Roberto AngioliFrancesco Plotti
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PignataS Tramontana
Feb 11, 2020·Expert Opinion on Pharmacotherapy·Luigi Della CorteGiuseppe Bifulco
Apr 17, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Charlotte MaeneIgnace Vergote

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