PMID: 16613576Apr 15, 2006Paper

Ifosfamide. Metabolic studies, new therapeutic approaches and new analogs

Mini Reviews in Medicinal Chemistry
Konrad Misiura

Abstract

Ifosfamide (IFO), an oxazaphosphorine-type anticancer alkylating agent, was found to be particularly useful in the treatment of a wide variety of neoplasm in adults and children. IFO is a positional isomer of cyclophosphamide (CPA) and was introduced into clinical practice in the 80s and has recently attracted much attention. Therapeutic application of high-dose IFO is limited by several side-effects; among them neurotoxicity and nephrotoxicity give the greatest concern. The presence of these side-effects is likely to be connected with the metabolism of this drug. In recent years there have been many studies aiming better understanding metabolism of this drug, employing new therapeutic approaches and preparing new analogs.

Citations

Mar 24, 2011·Anti-cancer Drugs·Lidia MazurMarta Stojak
May 16, 2012·Pharmacology & Therapeutics·Diren Beyoğlu, Jeffrey R Idle
Aug 26, 2015·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Yin LoFe-Lin Lin Wu

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