PMID: 8602459Mar 1, 1996Paper

Ig-isotype patterns of primary and secondary B cell responses to Plasmodium chabaudi chabaudi correlate with IFN-gamma and IL-4 cytokine production with CD45RB expression by CD4+ spleen cells

Scandinavian Journal of Immunology
Maria Regina D'Império LimaP Minóprio

Abstract

In this work, the authors analysed T and B lymphocyte subsets and cytokine production in the spleen of BALB/c mice during polyclonal lymphocyte activation (primary infection) and parasite-specific response to Plasmodium chabaudi chabaudi (secondary infection). The secondary response was evaluated in fully immunoprotected animals, 60 days after a chloroquine-cured infection. The authors observed that in polyclonal lymphocyte activation antibody-secreting cells of all isotypes increased, with predominance of IgG2a and IgG3 classes. At that time, IFN-gamma was largely produced, but IL-4/IL-5 were just slightly enhanced. In mice re-infected after 60 days, the Ig-isotype pattern was restricted to IgG1 and only IL-4/IL-5 were produced. In both responses, however, the levels of IL-2 were greatly reduced, while those of IL-10 were enhanced to similar levels. The different involvement of Th1 and Th2 cells in both responses was confirmed through analysis of CD45RB expression by CD4+ cells. The authors observed that CD45RBhigh cells were the major CD4+ subpopulation in primary infected mice, while CD45RBlow cells predominated in 60 days re-infected animals. Moreover, the great majority of activated (large) CD4+ cells in the primary infect...Continue Reading

Citations

Sep 19, 1998·Immunology·A C Da SilvaP Minoprio
Mar 2, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sandra Marcia MuxelMaria Regina D'Império Lima
May 18, 1999·Experimental Parasitology·L Favila-CastilloD Garcia-Tapia
Feb 13, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Karina R B BastosMaria Regina D'Império Lima
Jul 20, 2007·Scandinavian Journal of Immunology·S I Castillo-MéndezM R D'Império Lima
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Paula Freitas do RosárioMaria Regina D'Império Lima
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosa M EliasMaria Regina D'Império Lima

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