IG, TR and IgSF, MHC and MhcSF: what do we learn from the IMGT Colliers de Perles?

Briefings in Functional Genomics & Proteomics
Quentin KaasMarie-Paule Lefranc

Abstract

The immunoglobulin superfamily (IgSF) comprises the immunoglobulins (IG), T cell receptors (TR) and proteins that have the common feature of having at least one Ig-like domain. The major histocompatibility complex (MHC) superfamily (MhcSF) comprises, in addition to the MHC, proteins which share the common feature of having Mhc-like domains. IMGT, the international ImMunoGeneTics information system (http://imgt.cines.fr) has set up a unique numbering system and standardized 2D graphical representations, or IMGT Colliers de Perles, which take into account the structural features of the Ig-like and Mhc-like domains. In this article, we review the IMGT Scientific chart rules for the description of the IgSF (V and C types) and of the MhcSF (G type) domains. These rules are based on the IMGT-ONTOLOGY axioms and concepts and are applicable for the sequence and structure analysis, whatever the species, the IgSF or MhcSF protein, or the chain type. These IMGT Colliers de Perles are particularly useful for antibody engineering, sequence-structure analysis, visualization and comparison of positions for mutations, polymorphisms and contact analysis.

Citations

Nov 4, 2008·Nucleic Acids Research·Marie-Paule LefrancPatrice Duroux
Jul 31, 2010·Dermatology Research and Practice·Joel F G Cohen-SolalCatherine Sautès-Fridman
Feb 26, 2013·Theoretical Biology & Medical Modelling·Dimitrios VlachakisSophia Kossida
Dec 19, 2014·Biomolecules·Marie-Paule Lefranc
Jul 16, 2015·MAbs·Alexander BujotzekGuy Georges
Nov 8, 2014·Nucleic Acids Research·Marie-Paule LefrancSofia Kossida
Feb 3, 2015·Proteins·Alexander BujotzekGuy Georges
Jun 22, 2010·Biopolymers·Quentin Kaas, David J Craik
Sep 15, 2012·Chemistry & Biodiversity·Monika SoudiChristian Obinger
Sep 4, 2020·Biomedicines·Marie-Paule Lefranc, Gérard Lefranc
May 25, 2013·Journal of Computational Chemistry·Birgit HischenhuberBernhard Knapp
Dec 17, 2020·International Journal of Molecular Sciences·Dovile StravinskieneAurelija Zvirbliene
Apr 1, 2014·Microbiology Spectrum·Marie-Paule Lefranc
Nov 5, 2021·Frontiers in Immunology·Eva-Stina EdholmSusana Magadan
Jun 3, 2011·Cold Spring Harbor Protocols·Véronique GiudicelliMarie-Paule Lefranc
Jun 3, 2011·Cold Spring Harbor Protocols·Marie-Paule Lefranc

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