PMID: 9186786Jan 1, 1997Paper

Ig VH-dependent interaction between immunoglobulins and CD4

International Reviews of Immunology
P LenertM Zanetti

Abstract

CD4 interacts with the immunoglobulin (Ig)-VH domains by a virtue of its solvent-exposed C and C strands. These two strands also contribute to the full HIV-gp120 binding and participate significantly in binding to class II MHC molecules. In this paper we hypothesize that any high-affinity interaction between serum (or membrane-expressed) Ig and CD4 may have impact on early T cell activation events. The existing data provide evidence for different outcomes of a high affinity Ig/CD4 interaction on T cell proliferation and cytokine secretion: costimulation and inhibition. We will also discuss how a low affinity CD4/Ig interaction could play an important role in B cell stimulation initiated through surface Ig receptors, and how CD4 may be involved in shaping the B cell repertoire.

References

Jan 27, 1977·Nature·K AdetugboD S Secher
Oct 1, 1992·The Journal of Experimental Medicine·N K BandaT H Finkel
Nov 1, 1992·The Journal of Experimental Medicine·V A WallaceT W Mak
Jan 1, 1991·International Reviews of Immunology·P Lenert, M Zanetti
Jan 1, 1991·Annual Review of Immunology·D J Capon, R H Ward
Jun 29, 1990·Science·P LenertM Zanetti
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M K JenkinsR H Schwartz
Sep 1, 1994·European Journal of Immunology·A RahemtullaT W Mak
Sep 1, 1994·European Journal of Immunology·D R KohT W Mak
Aug 1, 1993·Current Opinion in Immunology·R S YeungT W Mak
Jul 1, 1993·The Journal of Experimental Medicine·J L HillsonE H Sasso
Aug 19, 1993·Nature·N Killeen, D R Littman
Jan 1, 1993·Advances in Immunology·M C Miceli, J R Parnes
Dec 1, 1995·Immunological Reviews·H W MittrückerT W Mak

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Citations

Sep 14, 2001·Scandinavian Journal of Immunology·S MullerH Kohler

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