IgA and IgG2 deficiency associated with zonisamide therapy: a case report

Epilepsia
Y MaeokaK Takeshita

Abstract

To report a previously undescribed adverse effect, IgA/IgG subclass deficiency associated with zonisamide (ZNS) therapy. Serum IgA and IgG subclass levels were determined by the turbidimetric immunoassay and enzyme-linked immunosorbent assay, respectively, in a 2-year-old boy with postmeningitis sequelae who was treated by ZNS. Four months after initiation of ZNS, combined deficiency of IgA and IgG2 was noted. After cessation of ZNS, serum IgA level was promptly increased. IgG2 level was gradually increased, but remained subnormal after 7 months. This case documents, for the first time, the action of ZNS on IgG immune system as well as IgA system. If patients with ZNS therapy showed IgA deficiency and recurrent infections, it is preferable to check serum IgG subclass concentrations as well.

References

Oct 4, 1975·Lancet·J SeagerJ F Soothill
May 7, 1977·Lancet·D R StanworthR Thompson
Jul 1, 1978·Journal of Neurology, Neurosurgery, and Psychiatry·A FontanaP Grob
Aug 1, 1992·Acta Paediatrica·A IshizakaS Matsumoto
Mar 1, 1989·Journal of Neurology·N E Gilhus, T Lea
Mar 1, 1986·The Journal of Pediatrics·F E Leickly, R H Buckley
Apr 1, 1986·The Journal of Allergy and Clinical Immunology·I C GuerraW T Shearer
May 1, 1988·Epilepsia·N E Gilhus, T Lea
Apr 1, 1993·Acta Paediatrica Japonica; Overseas Edition·H HayashibaraK Shiraki

❮ Previous
Next ❯

Citations

Apr 12, 2001·European Journal of Internal Medicine·D VoutsinasN Galanakis
Aug 7, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Antoine E Azar, Zuhair K Ballas
Mar 3, 2010·CNS Drugs·Dean P Sarco, Blaise F D Bourgeois
May 3, 2000·Clinical and Experimental Immunology·L HammarströmD Webster
Jul 29, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·I C Wong, S D Lhatoo
Feb 11, 2005·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·An D BilliauLieven G Lagae
Jul 4, 2012·Epilepsy Research·Suvi LiimatainenJukka Peltola
Jul 12, 2016·Brain & Development·Shinsuke MaruyamaYoshifumi Kawano
Mar 26, 2003·European Journal of Pediatrics·Zenichiro KatoNaomi Kondo
Apr 17, 2004·Clinical and Experimental Immunology·T AsanoN Kondo
Aug 1, 2019·Archivum Immunologiae Et Therapiae Experimentalis·Amrita Khokar, Sudhir Gupta

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.