PMID: 6169655Feb 15, 1981Paper

IgA antibody, antibody-dependent cellular cytotoxicity and prognosis in patients with nasopharyngeal carcinoma

International Journal of Cancer. Journal International Du Cancer
G D MathewG R Pearson

Abstract

Immunoglobulin fractions containing antibodies to the Epstein-Barr virus (EBV) were isolated from different sera and tested in the antibody-dependent cellular cytotoxicity (ADCC) assay. All cytotoxic activity resided in the IgG fraction. IgA antibodies were not cytotoxic in this assay against cells expressing the EBV-induced membrane antigen complex. However, IgA antibodies were able to block the IgG-mediated ADCC reaction, indicating that the IgA and IgG antibodies recognized the same EVB-specific antigenic determinants. This was supported by results from radioimmune precipitation experiments. Our findings suggest that low ADCC titers previously identified in the sera of patients with nasopharyngeal carcinoma (NPC) who had a poor prognosis could be due to the blocking activity of IgA antibodies. The results further suggest that IgA antibodies are detrimental to the patient with this disease, if one assumes that ADCC functions in vivo in immunity to this tumor

References

Oct 15, 1979·International Journal of Cancer. Journal International Du Cancer·G R PearsonI S Bal
Jan 1, 1978·Current Topics in Microbiology and Immunology·G R Pearson
Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·G Henle, W Henle
Mar 1, 1976·Journal of the National Cancer Institute·G R Pearson, T W Orr
Nov 15, 1976·International Journal of Cancer. Journal International Du Cancer·J M PrevostL F Qualtiere
Jan 1, 1977·Annual Review of Microbiology·M A Epstein, B G Achong
Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·W HenleH C Kwan
Aug 15, 1978·International Journal of Cancer. Journal International Du Cancer·G R PearsonG Klein
Nov 2, 1976·The Journal of Experimental Medicine·B WåhlinP Perlmann
Sep 15, 1971·International Journal of Cancer. Journal International Du Cancer·G HenleG Klein

❮ Previous
Next ❯

Citations

Jan 1, 1985·Journal of Cancer Research and Clinical Oncology·A FaggioniV Manzari
Jul 11, 2012·Journal of Clinical Immunology·Jaroslava PribylovaHelena Tlaskalova-Hogenova
Apr 6, 2012·The New England Journal of Medicine·Barton F HaynesJerome H Kim
May 11, 2013·Proceedings of the National Academy of Sciences of the United States of America·Georgia D TomarasBarton F Haynes
Jul 28, 2012·EMBO Molecular Medicine·Daniel M CzajkowskyRichard J Pleass
Nov 8, 2012·Expert Opinion on Biological Therapy·Harriet L Robinson
Jun 19, 1991·International Journal of Cancer. Journal International Du Cancer·M KhyattiJ Menezes
Aug 1, 1986·Cellular Immunology·K KomiyamaJ Mestecky
Feb 15, 1982·International Journal of Cancer. Journal International Du Cancer·R F NaegeleW Henle
Apr 15, 1988·International Journal of Cancer. Journal International Du Cancer·W C UenG R Pearson
Aug 15, 1988·International Journal of Cancer. Journal International Du Cancer·F de-VathaireY Cachin
Apr 15, 1989·International Journal of Cancer. Journal International Du Cancer·M LakhdarR Kastally
Jun 15, 1984·International Journal of Cancer. Journal International Du Cancer·G R PearsonB Pilch
Nov 15, 1982·International Journal of Cancer. Journal International Du Cancer·R S TanJ Champion
Jan 1, 1989·Critical Reviews in Oncology/hematology·R H Giller, C Grose
Jan 31, 2017·Immunological Reviews·David M MargolisGuido Ferrari
Jan 31, 2017·Immunological Reviews·Georgia D Tomaras, Stanley A Plotkin
Apr 24, 2014·Therapeutic Advances in Vaccines·Yehuda Z Cohen, Raphael Dolin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Related Papers

Comparative Immunology, Microbiology and Infectious Diseases
T C Lynn, S M Tu
Expert Review of Vaccines
Sorachai NitayaphanJean-Louis Excler
Journal of Biochemistry
Hiroaki NagashimaYasuhiko Masuho
© 2021 Meta ULC. All rights reserved