IgA attenuates anaphylaxis and subsequent immune responses in mice: possible application of IgA to vaccines

Immunologic Research
Kouya YamakiShin Yoshino

Abstract

Administration of the influenza vaccination to patients with an egg allergy is major health concern. Contaminating egg antigens occasionally induce severe anaphylactic shock in these patients following administration of the vaccination; therefore, the development of a safer vaccination is needed. In the present study, we investigated whether a mixture of four newly and previously generated anti-ovalbumin (OVA) IgA monoclonal antibodies (mAbs) could inhibit both anaphylactic shock upon a subcutaneous OVA challenge and subsequent further sensitization against OVA in passively anti-OVA IgE-sensitized mice and actively sensitized mice with an injection of OVA. The prevention of anaphylaxis by anti-OVA IgA mAbs was suggested to be mediated through the inhibition of OVA binding to allergenic antibodies such as anti-OVA IgE on mast cells and deceleration of the rate of OVA penetration from the injected site into the systemic circulation. Anti-OVA IgA mAbs inhibited further sensitization against OVA in mice actively sensitized with OVA, but did not affect sensitization against the unrelated antigen, phosphorylcholine-keyhole limpet hemocyanin co-injected with OVA. Our findings indicate that adding the anti-egg antigen IgA to the influe...Continue Reading

References

Jul 1, 1993·European Journal of Immunology·B HeymanS Gustavsson
Aug 12, 1998·American Journal of Respiratory and Critical Care Medicine·J SchwarzeE W Gelfand
Jul 6, 2004·The Journal of Pharmacy and Pharmacology·Kouya YamakiShin Yoshino
Aug 22, 2006·Scandinavian Journal of Immunology·F HjelmB Heyman
Jan 15, 2008·Clinical and Experimental Immunology·P A EigenmannC P Frossard
Jan 19, 2008·Journal of Clinical Immunology·Cristina M A JacobRenato C Monteiro
May 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fredrik HjelmBirgitta Heyman
Sep 19, 2008·The New England Journal of Medicine·Gideon Lack
Mar 24, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A-C LundellA Rudin
Dec 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Simpson, F D Martinez
Jun 4, 2010·Chemical Immunology and Allergy·Janet Kalesnikoff, Stephen J Galli
Jun 29, 2010·The Journal of Allergy and Clinical Immunology·Remi GagnonUNKNOWN PHAC-CIHR Influenza Research Network
Oct 30, 2010·Biochemical and Biophysical Research Communications·Ryosuke IshikawaHajime Karasuyama
Mar 26, 2011·The Journal of Clinical Investigation·Friederike JönssonPierre Bruhns
Jun 22, 2011·MAbs·Jantine E Bakema, Marjolein van Egmond
Sep 12, 2012·Pediatrics·UNKNOWN Committee on Infectious Diseases, American Academy of Pediatrics
Oct 2, 2012·The Journal of Allergy and Clinical Immunology·Anne Des RochesUNKNOWN PCIRN (Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network)
Jul 23, 2013·Frontiers in Immunology·Blaise Corthésy
Aug 2, 2013·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Robert A Wood
Aug 9, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julien DianaRenato C Monteiro

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.