IgA Deficiency and Membranoproliferative Glomerulonephritis: A Case Report.

International Medical Case Reports Journal
Alessandro PezzuttoMario Bonomini

Abstract

Immunoglobulin A deficiency (IgAD) is the most common form of primary immunodeficiency in western countries. It can be associated with the development of autoimmune diseases both in adults and in children even though the exact pathophysiology is not fully defined. We report here a case of a young patient who developed nephrotic syndrome secondary to membranoproliferative glomerulonephritis associated with the incidental finding of IgAD. We began corticosteroid therapy and angiotensin-converting enzyme inhibitor, and we observed partial remission of the nephrotic syndrome after about nine months; nonetheless, in the following follow-up visits, a progressive decline of renal function was found. Our case extends the spectrum of hitherto described glomerulonephritides associated with IgAD which were described until now.

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