PMID: 9175025Jan 1, 1997Paper

IgA deficiency and SLE: prevalence in a clinic population and a review of the literature

Lupus
E C Rankin, D A Isenberg

Abstract

An association between systemic lupus erythematosus (SLE) and immunoglobulin A (IgA) deficiency has been reported previously and may have therapeutic consequences for patients who require treatment with intravenous immunoglobulin. We report the prevalence of IgA deficiency in a clinic population of 96 patients with SLE. Five patients were found to be consistently IgA deficient. These patients were more likely to be West Indian, to have anti-Sm and anti-La antibodies and to have a speckled pattern of antinuclear antibody. There were no significant differences in clinical features between IgA deficient and other SLE patients, nor in SLE-related HLA alleles. We thus confirm the increased prevalence of IgA deficiency in patients with SLE. A review of the literature is presented and we speculate on the nature of the link between IgA deficiency and SLE.

References

May 7, 1977·Lancet·D R StanworthR Thompson
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·O OlerupL Hammarström
Jan 1, 1992·International Archives of Allergy and Immunology·R S Liblau, J F Bach
Jan 1, 1991·Immunologic Research·Y C LinJ Stavnezer
Aug 1, 1990·Immunology Today·M A French, R L Dawkins
Feb 1, 1990·Clinical and Experimental Immunology·S HashimotoC McCombs
Mar 1, 1988·The American Journal of Medicine·G L Clementz, B J Dolin
Sep 1, 1987·The Journal of Experimental Medicine·J H KehrlA S Fauci
Jun 1, 1988·Archives of Disease in Childhood·G Morgan, R J Levinsky
Jan 30, 1969·The New England Journal of Medicine·J T CassidyD Sullivan
May 14, 1983·British Medical Journal·J P DelamereK A Grindulis
Aug 1, 1983·American Journal of Clinical Pathology·J A ClarkD M Smith
Jan 1, 1983·Scandinavian Journal of Rheumatology·P PelkonenA L Mäkelä
Aug 27, 1981·The New England Journal of Medicine·M E Conley, M D Cooper
Jun 11, 1981·The New England Journal of Medicine·V A OxeliusL A Hanson
Jan 1, 1994·European Journal of Immunology·A G WilsonG W Duff
Jul 1, 1993·Journal of Clinical Immunology·C Cunningham-RundlesS Courter

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Citations

Mar 11, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Zsuzsanna PálMaria Judit Molnar
Oct 25, 2006·Springer Seminars in Immunopathology·Akira Shibuya, Shin-Ichiro Honda
Jan 18, 2005·Rheumatology International·Antonio G Tristano
Dec 31, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Kazuhide SuyamaMitsuaki Hosoya
Apr 28, 2007·Journal of Clinical Immunology·Ulrich SalzerBodo Grimbacher
Apr 12, 2008·Journal of Clinical Immunology·Magda Carneiro-SampaioMaria Helena Kiss
Oct 17, 2009·Journal of Clinical Immunology·Javad MohammadiLennart Hammarström
Oct 3, 2000·Arthritis and Rheumatism·M ZaporD F Battafarano
Jul 14, 2001·Molecular Immunology·M Boes
Apr 5, 2000·The Journal of Experimental Medicine·M R EhrensteinM S Neuberger
Aug 27, 2015·Expert Review of Clinical Immunology·Reza YazdaniAsghar Aghamohammadi
Jan 30, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·K T ParkDorsey Bass
Jun 15, 2011·Journal of Neuroimmunology·Ryan RamanujamLennart Hammarström
Mar 8, 2011·Neurología : publicación oficial de la Sociedad Española de Neurología·A J Remolina LópezE Cristiano
Aug 14, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Iglika Djoumerska-AlexievaAndrey Tchorbanov
Jan 27, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Gudmundur H JorgensenBjorn R Ludviksson
Feb 29, 2016·Reumatología clinica·Francisco Rivas-Larrauri, Marco Antonio Yamazaki-Nakashimada
Oct 26, 2013·Autoimmunity Reviews·Karmtej SinghM Eric Gershwin
Nov 6, 2014·Journal of Clinical Immunology·Che Kang LimLennart Hammarström
Apr 26, 2006·Lupus·M Y Karim
Aug 10, 2011·Molecular Medicine·Ning WangLennart Hammarström
Jul 4, 2019·Clinical Reviews in Allergy & Immunology·David D Odineal, M Eric Gershwin
Nov 30, 2000·Current Treatment Options in Neurology·M G Navarrete, R L Brey
May 3, 2019·Pediatrics in Review·Ivan K Chinn, Jordan S Orange
Oct 22, 2019·Therapeutic Advances in Neurological Disorders·Greta ZoehnerMaria Eleftheria Evangelopoulos
Mar 30, 2021·Lupus·Ibrahim AlmaghlouthMurray Urowitz
Aug 9, 2021·La Revue de médecine interne·L LucaM Martin

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