PMID: 9161953May 1, 1997Paper

IgA endomysium antibodies on human umbilical cord: an excellent diagnostic tool for celiac disease in childhood

Journal of Pediatric Gastroenterology and Nutrition
K L Kolho, E Savilahti

Abstract

An improvement in screening for celiac disease has recently been described that uses human umbilical cord as a substitute for monkey esophagus to determine IgA endomysium antibodies in adults. As using monkey esophagus is ethically questionable for large-scale screening, we studied whether substitution of umbilical cord would be suitable for pediatric patients as well. Serum from 53 children with untreated celiac disease, 22 in remission and 13 on challenge, were screened for antigliadin IgA, antigliadin IgG, and IgA reticulin antibodies, in addition to IgA endomysium antibodies tested both on monkey esophagus and on human umbilical cord. Controls included 20 patients with cow-milk-sensitive enteropathy, 23 with inflammatory bowel disease, and 23 with diabetes mellitus, and 48 patients who were biopsied to exclude celiac disease either because of positive gliadin antibody test or disturbed growth. Sensitivity (0.94) and specificity (1.0) were similar for umbilical cord and esophageal determinations in active celiac disease. Both substrates detected identical positive cases and neither gave false-positive results. In celiac patients on a gluten-free diet, endomysium antibodies with either substrate were positive in seven identic...Continue Reading

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Citations

Jun 2, 2007·Gastroentérologie Clinique Et Biologique·Amani MankaïIbtissem Ghedira
May 2, 2002·Clinical and Experimental Immunology·M Westerholm-OrmioE Savilahti
Feb 19, 1998·Scandinavian Journal of Immunology·P KlemettiO Vaarala
Aug 14, 1998·Journal of Pediatric Gastroenterology and Nutrition·S SulkanenM Mäki
Jan 6, 2001·Journal of Pediatric Gastroenterology and Nutrition·M Stern, UNKNOWN Working Group on Serologic Screening for Celiac Disease
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·K L KolhoE Savilahti
Feb 3, 2018·European Journal of Pediatrics·Michael W Van KalleveenFrans B Plötz
Dec 7, 2017·Journal of Pediatric Gastroenterology and Nutrition·Emma Merike SavilahtiMikael Kuitunen
May 16, 2000·The American Journal of Gastroenterology·D SblatteroT Not
Mar 11, 2010·Journal of Pediatric Gastroenterology and Nutrition·Mia Westerholm-OrmioErkki Savilahti
Dec 28, 2006·Scandinavian Journal of Gastroenterology·Sari TikkakoskiKaija-Leena Kolho
Dec 6, 2006·Annals of Saudi Medicine·Rabab Ali Al Attas
Nov 1, 2001·Paediatrics & Child Health·R Lad, K Jacobson

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