Jun 9, 2020Paper

IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity

BioRxiv : the Preprint Server for Biology
Monir EjemelYang Wang

Abstract

COVID-19 caused by SARS-CoV-2 has become a global pandemic requiring the development of interventions for the prevention or treatment to curtail mortality and morbidity. No vaccine to boost mucosal immunity or as a therapeutic has yet been developed to SARS-CoV-2. In this study we discover and characterize a cross-reactive human IgA monoclonal antibody, MAb362. MAb362 binds to both SARS-CoV and SARS-CoV-2 spike proteins and competitively blocks hACE2 receptor binding, by completely overlapping the hACE2 structural binding epitope. Furthermore, MAb362 IgA neutralizes both pseudotyped SARS-CoV and SARS-CoV-2 in human epithelial cells expressing hACE2. SARS-CoV-2 specific IgA antibodies, such as MAb362, may provide effective immunity against SARS-CoV-2 by inducing mucosal immunity within the respiratory system, a potentially critical feature of an effective vaccine.

Citations

Jun 28, 2020·Journal of Virology·John P Moore, P J Klasse
Jan 15, 2021·Immunological Medicine·Norma Saad, Salim Moussa

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