IgA nephropathy in kidney allograft recipients-therapeutic perspective

Transplantation Proceedings
J PazikM Durlik

Abstract

A growing number of patients are losing their kidney allografts due to glomerulonephritis. Although posttransplant IgA nephropathy (IgAN) is regarded as benign, it may lead to late allograft loss in a substantial number of patients. The aim of this study was to evaluate the influence of posttransplant IgAN on long-term transplantation outcomes, risk factors for progression of graft dysfunction, and effectiveness of therapeutic interventions. We evaluated, potential risk factors for accelerated graft loss among 27 kidney allograft recipients with posttransplant IgAN, comparing graft survival in a control group matched for population and transplantation-related parameters. We evaluated the effectiveness of therapeutic interventions regarding immunosuppressive regimen, and hypertension control including angiotensin converting enzyme inhibitor (ACEI) usage with Kaplan-Meier, Cox proportional hazard plots, and log-rank tests in statistical analyses. Compared with the control group, patients with IgAN experienced a 6.57 higher risk for dialysis dependence (P < .01, 95% CI 1.4 to 30.83). The risk for accelerated graft loss in the course of IgAN was associated with graft dysfunction (RR = 2.16 for additional 1 mg/dL of serum creatinine...Continue Reading

References

Mar 15, 1997·Lancet·R NowackF J van der Woude
Sep 5, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A Y WangP K Li
Nov 13, 2001·Kidney International·C PonticelliA Tarantino
Feb 19, 2002·Kidney International·Michael J ChoiWilliam A Briggs
Sep 6, 2002·The New England Journal of Medicine·James V Donadio, Joseph P Grande
Jun 17, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jürgen Floege
Oct 2, 2004·Kidney International·Vincenzo SepeAntonio Dal Canton

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Citations

Dec 19, 2006·Transplantation Proceedings·F Carneiro-RozaG Mastroianni-Kirsztajn

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