IgA nephropathy: the presence of familial disease does not confer an increased risk for progression

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
C IzziF Scolari

Abstract

Immunoglobulin A (IgA) nephropathy is the most common form of glomerulonephritis worldwide. Familial and sporadic cases are recognized, and a locus associated with the familial form of the disease was mapped to chromosome 6. Recent data suggest the familial IgA nephropathy form may have a poorer outcome than the sporadic form. We tested the hypothesis of unequal survival rates between the 2 forms of disease by analyzing time from biopsy to end-stage renal disease in patients of Italian ancestry; 589 patients with sporadic and 96 patients with familial IgA nephropathy. Overall 10- and 20-year renal survival probabilities of the cohort as a whole were 71% and 50%, respectively. Macroscopic hematuria was the modality of clinical presentation in 51% of patients with familial IgA nephropathy and 39% of patients with sporadic IgA nephropathy. At univariable analysis, the sporadic form of IgA nephropathy was associated significantly with increased risk for renal death. However, patients with the sporadic form tended to be more hypertensive and diagnosed later, with signs of more advanced renal disease than those with familial disease at baseline. In the regression model, form of disease lost any independent effect. Only male sex, lowe...Continue Reading

References

Jul 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·E AlamartineF Berthoux
Nov 1, 1988·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B A JulianR J Wyatt
Jun 1, 1982·Archives of Internal Medicine·M VallésM Carrera
Jan 1, 1993·Contributions to Nephrology·M Levy
Feb 1, 1997·Journal of the American Society of Nephrology : JASN·M G RadfordJ P Grande
Apr 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F ScolariR Maiorca
Aug 3, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G D'Amico
Nov 30, 2000·Journal of the American Society of Nephrology : JASN·Jürgen Floege, John Feehally
Mar 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·F BonnetF Berthoux
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·L P BartosikD C Cattran
Jan 24, 2002·Journal of the American Society of Nephrology : JASN·Francesco Paolo SchenaCarlo Manno
Sep 6, 2002·The New England Journal of Medicine·James V Donadio, Joseph P Grande
Aug 5, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Colin C GeddesDaniel C Cattran
Jun 19, 2004·Current Opinion in Nephrology and Hypertension·Bruce A Julian, Jan Novak
Jun 16, 2005·Kidney International·Marcello TonelliUNKNOWN Cholesterol and Recurrent Events (CARE) Trial Investigators

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Citations

Jun 12, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Masashi GotoYasuhiko Tomino
Jan 30, 2014·Journal of Nephropathology·Elham Ibrahim SeifManal Ibrahim Salman
May 18, 2010·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ryohei YamamotoYoshitaka Isaka
Jan 29, 2008·Seminars in Nephrology·Stephen I-Hong Hsu
May 26, 2007·Nature Clinical Practice. Nephrology·Isabel BeermanAli G Gharavi
Nov 16, 2007·Electrophoresis·Bruce A JulianBrendan M McGuire
Mar 21, 2012·Nature Reviews. Nephrology·Kar Neng Lai
Jan 12, 2021·KI Reports·Manman ShiJingyuan Xie

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