IgA polymorphism in mice: individual light chains can pair covalently with some alpha heavy chains and non-covalently with others

Molecular Immunology
A M StaniszJ M Davie


The molecular basis for the two different forms of IgA in mice, distinguished by the covalent or non-covalent association of light (L) and heavy (H) chains, is unknown. In this communication, we show, using somatic cell hybridization to construct cells producing new combinations of alpha and L chains, that individual L chains probably can pair both covalently and non-covalently depending on the alpha chain.


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Dec 31, 2010·Journal of Virology·Guiqing HuKenneth H Roux

Related Concepts

Hybrid Cells
Immunoglobulin alpha-Chains
Immunoglobulin Light Chains
Mouse, Swiss

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