IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up-regulation CD80/CD86 co-stimulatory molecules

European Journal of Immunology
Robert BrinkAntony Basten

Abstract

The expression and function of IgM and IgD antigen receptors were studied in a series of anti-hen egg lysozymes (HEL) immunoglobulin (Ig)-transgenic mice expressing either IgM alone, IgD alone, or both IgM and IgD. B cell surface expression of IgD was found to be more efficient than that of IgM. Thus antigen receptor density on IgD+, IgM- B cells was twofold higher than on IgM+, IgD- B cells despite the presence of sevenfold lower levels of membrane heavy chain mRNA, and coexpression of IgD with IgM led to almost complete inhibition of surface IgM. In addition, less extensive down-regulation of IgD occurred following exposure to antigen in vitro. When regulation of CD80/CD86 co-stimulatory molecules by surface Ig was examined, up-regulation of the former was initiated at lower antigen concentrations on IgM-, IgD+ compared to IgM+, IgD- B cells. On correcting for antigen receptor density, however, induction of CD80/CD86 by IgM and IgD was comparable. Taken together, these results reinforced the functional similarity of IgM and IgD antigen receptors while at the same time revealing differences in expression which may explain their simultaneous presence on mature B cells.

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Citations

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Sep 10, 2015·European Journal of Immunology·Rudolf Übelhart, Hassan Jumaa
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Mar 8, 2013·The Journal of Allergy and Clinical Immunology·Kathrin PieperHermann Eibel
May 8, 2018·European Journal of Immunology·Cindy GutzeitAndrea Cerutti
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Jan 8, 2021·International Reviews of Immunology·Tue Gia Nguyen
May 15, 2021·Immunology and Cell Biology·Zhiguo ZhangJoanne H Reed

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