IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function

The Journal of Experimental Medicine
Laurence E ChengRichard M Locksley

Abstract

Vertebrate immunity has evolved a modular architecture in response to perturbations. Allergic inflammation represents such a module, with signature features of antigen-specific IgE and tissue eosinophilia, although the cellular and molecular circuitry coupling these responses remains unclear. Here, we use genetic and imaging approaches in models of IgE-dependent eosinophilic dermatitis to demonstrate a requisite role for basophils. After antigenic inflammation, basophils initiate transmigration like other granulocytes but, upon activation via their high-affinity IgE receptor, alter their migratory kinetics to persist at the endothelium. Prolonged basophil-endothelial interactions, in part dependent on activation of focal adhesion kinases, promote delivery of basophil-derived IL-4 to the endothelium and subsequent induction of endothelial vascular cell adhesion molecule-1 (VCAM-1), which is required for eosinophil accumulation. Thus, basophils are gatekeepers that link adaptive immunity with innate effector programs by altering access to tissue sites by activation-induced interactions with the endothelium.

References

Mar 1, 1991·The Journal of Experimental Medicine·K MiyakeP W Kincade
Jan 16, 1982·Lancet·E B MitchellT A Platts-Mills
Mar 30, 2001·The Journal of Biological Chemistry· Hirata KiT Quertermous
Mar 20, 2004·Immunity·David VoehringerRichard M Locksley
May 19, 2004·Allergy·D SimonH-U Simon
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·André GessnerMarkus Mohrs
Feb 3, 2005·Nature Reviews. Molecular Cell Biology·Satyajit K MitraDavid D Schlaepfer
Sep 18, 2007·American Journal of Respiratory and Critical Care Medicine·Patrick Flood-PageUNKNOWN International Mepolizumab Study Group
Nov 1, 2007·Transgenic Research·Julia ScholtenAxel Roers
Feb 27, 2008·Nature Immunology·Caroline L SokolRuslan Medzhitov
Feb 28, 2008·Nature Reviews. Immunology·Hannah J Gould, Brian J Sutton
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·David VoehringerRichard M Locksley
Jul 25, 2008·Nature·Ruslan Medzhitov
Mar 7, 2009·The New England Journal of Medicine·Pranabashis HaldarIan D Pavord
Jun 2, 2009·American Journal of Respiratory and Critical Care Medicine·Prescott G WoodruffJohn V Fahy
Jan 30, 2010·The Journal of Allergy and Clinical Immunology·Mark Boguniewicz, Donald Y M Leung
Apr 8, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Tomoko MatsudaYasuyuki Imai
Jun 29, 2010·European Journal of Immunology·Stephen J Galli, Mindy Tsai
Sep 28, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laurence E ChengRichard M Locksley
Dec 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lynn A KamenClifford A Lowell
Jan 21, 2011·Clinical Reviews in Allergy & Immunology·Fu-Tong LiuHuan-Yuan Chen
May 10, 2011·Nature Immunology·Brandon M SullivanRichard M Locksley
Nov 17, 2011·Biochemical and Biophysical Research Communications·Hirofumi YamagishiHajime Karasuyama
Feb 26, 2013·Nature Reviews. Immunology·Elzbieta Kolaczkowska, Paul Kubes

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Citations

Aug 19, 2015·Frontiers in Immunology·Marika SarfatiGuy Delespesse
May 11, 2016·Seminars in Immunopathology·Yoshinori Yamanishi, Hajime Karasuyama
May 15, 2016·Seminars in Immunopathology·Landon K OetjenBrian S Kim
May 12, 2016·Scandinavian Journal of Immunology·K AminJ Bystrom
Dec 3, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B R HagmannM Fux
Apr 10, 2017·The Journal of Allergy and Clinical Immunology·Maryam HussainMario Noti
Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kensuke MiyakeHajime Karasuyama
Feb 13, 2018·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·P KorošecP J Turner
Jun 28, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·John T Schroeder, Anja P Bieneman
Sep 12, 2017·Nature Reviews. Immunology·Peter F Weller, Lisa A Spencer
Jun 13, 2018·Experimental Dermatology·Takashi HashimotoGil Yosipovitch
Sep 5, 2017·F1000Research·David Voehringer
Apr 4, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·Ying GuJianzhong Zhang
Jun 3, 2020·The Journal of Clinical Investigation·Melanie C DispenzaBruce S Bochner
Jan 18, 2017·Journal of Immunology Research·Arnau Navinés-FerrerMargarita Martín
Nov 18, 2015·Current Opinion in Pulmonary Medicine·Alex KleinJan
Jun 1, 2017·Allergy·M Fux, C von Garnier
Jan 16, 2020·Scientific Reports·Lionel RohnerMichaela Fux
Jan 8, 2020·The Journal of Dermatology·Keiko InuiHiroo Yokozeki
Sep 26, 2019·Frontiers in Immunology·Christophe PellefiguesGraham Le Gros
Nov 19, 2020·Allergy·Kensuke MiyakeHajime Karasuyama
Nov 24, 2016·Cancer Research·Ibrahim M SektiogluGünter J Hämmerling
Dec 29, 2020·Frontiers in Immunology·Anna Marianne WeijlerThomas Wekerle
Mar 24, 2020·Archivos de bronconeumología·María Del Mar García RódenasFrancisco M Marco de la Calle
Oct 19, 2017·The Journal of Allergy and Clinical Immunology·Jeremy A O'Sullivan, Bruce S Bochner
Mar 5, 2021·The Journal of Allergy and Clinical Immunology·Christophe PellefiguesGraham Le Gros
May 21, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Benjamin L WrightR Sharon Chinthrajah
Nov 18, 2018·Journal of Molecular and Cellular Cardiology·Jes-Niels BoeckelTill Keller
May 20, 2021·Seminars in Immunopathology·Julien Catherine, Florence Roufosse
May 12, 2021·JCI Insight·Maya E KotasBenjamin Terrier

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Methods Mentioned

BETA
confocal microscopy
flow cytometry
transgenic

Software Mentioned

GraphPad
Prism
FlowJo
AxioVision

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