PMID: 8939162Nov 1, 1996Paper

IgE against HIV proteins in clinically healthy children with HIV disease

The Journal of Allergy and Clinical Immunology
E A SecordH G Durkin

Abstract

Elevated serum Ige was detected in 26% (7 of 30) of children with HIV infection. The majority of children with elevated IgE were of one ethnic group (Puerto Rican) (4 of 7), compared with only 9% (2 of 23) in the normal to low IgE group (p = 0.02). Most of the children with elevated IgE had decreased circulating CD4+ T cells (5 of 7 or 71%); but none had opportunistic infections, and none failed to thrive. Although similar numbers of children with normal to low IgE had decreased circulating CD4+ T cells (19 of 23 or 83%), this group had opportunistic infections (6 of 23 or 26%) and failure to thrive (7 of 30 or 30%). There was no difference in incidence of allergic symptoms between groups. IgE antibody against HIV protein was detected by Western blot technique in the sera of three children with elevated serum IgE. Thus we have identified a group of children with HIV infection and elevated serum IgE of predominantly one ethnic group, who are without opportunistic infections or failure to thrive, some of whom produce HIV-specific IgE. This suggests that IgE may play a protective (perhaps late compensatory) role in HIV disease in genetically predisposed individuals.

References

Jan 1, 1992·The Journal of Allergy and Clinical Immunology·D Israël-BietP Even
Feb 1, 1988·AIDS Research and Human Retroviruses·J KhalifeA Capron
Feb 1, 1995·The Journal of Allergy and Clinical Immunology·A ViganóA Salvaggio

❮ Previous
Next ❯

Citations

Jun 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Faina GutinElizabeth Secord
Jun 30, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M CorominasE Buendia
Feb 25, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M L de AsisC B Small
Aug 19, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Martin H BluthTamar A Smith-Norowitz
Apr 3, 2001·AIDS Research and Human Retroviruses·L S MillerH G Durkin
Mar 19, 2002·AIDS Research and Human Retroviruses·Michael G PellegrinoHelen G Durkin
Feb 25, 2010·Clinical and Molecular Allergy : CMA·Mariah B PateGuha Krishnaswamy
Mar 31, 2011·International Journal of Medical Sciences·Tamar A Smith-NorowitzMartin H Bluth
Dec 23, 2015·Nature Immunology·Jill HenaultMiguel A Sanjuan
Mar 16, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Corinna S BowserH Jack Moallem
Jun 16, 2015·Human Immunology·Tamar A Smith-NorowitzStephan Kohlhoff
Jul 19, 2015·Journal of Translational Medicine·Andargachew MuluSisay Yifru
Jul 6, 2014·Journal of Clinical Pathology·Shireen McVicker, M Yousuf Karim
Jul 22, 2016·Irish Journal of Medical Science·T A Smith-NorowitzS Kohlhoff
Jun 1, 2010·Memórias do Instituto Oswaldo Cruz·Cristina Rodrigues CruzHermenio Cavalcante Lima
Nov 15, 2002·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Heather J ZarGregory Hussey
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·V PatellaG Marone
Nov 12, 2020·Journal of Clinical Medicine·Kevin WongVishwanath Venketaraman
Jul 23, 2014·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Leandro S LinharJane da Silva

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.