IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper.

The World Allergy Organization Journal
Ignacio J AnsoteguiTorsten Zuberbier

Abstract

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.

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Methods Mentioned

BETA
Assay
ELISA
sandwich immunoassay
chip
glycosylation
enzyme-linked immunosorbent assays
chips
Fluorescence-Activated Cell Sorting
flow cytometry
enzyme-linked immunosorbent assay

Software Mentioned

HistaFlow
ALEX
Allergenius
ALlergen EXplorer
MacroArrayDX
MBAD
GA
MAST
ImmunoCAP
Viravaxx

Related Concepts

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Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

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