PMID: 752256Nov 1, 1978Paper

IgE and complement in allergic children

Allergologia et immunopathologia
J Costa TrindadeN G Ferreira

Abstract

The following measurements were made using radial immunodiffusion with commercial M-Partigen plaques (Behringwerke, Marburg): Global-IgE in the serum of 29 children (17 atopic asthmas, 3 non atopic asthmas and 9 acute urticarias); C3 and C4 complement fractions in 56 patients (27 atopic asthmas, 11 non atopic asthmas and 18 acute urticarias); C3PA complement fraction in 41 patients (18 atopic asthmas, 9 non atopic asthmas and 14 acute urticarias). High IgE serum levels were observed chiefly in the cases of atopic asthma with polysensitization and in urticarias. The anomaly of the complement system most often found in children was an increase of C4 (23,2% of the cases), not related to the clinical form or duration of the disease. An increase of the C3 fraction (14,6% of the cases) was also observed together with an increase of these two fractions in all the cases where an increase of C3PA was observed. Only in 11,1% of atopic asthmas was a decrease of the serum concentration values of C3 observed.

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.