Mar 1, 1986

IgE antibody-mediated shock reaction caused by topical application of chlorhexidine

Clinical Allergy
T OhtoshiM Muranaka

Abstract

A case of an anaphylactic shock following topical application of chlorhexidine preparation is reported. Specific skin-sensitizing antibodies against chlorhexidine were demonstrated in the serum from the patient by a passive transfer test. IgE antibodies against chlorhexidine were also detected by radioallergosorbent technique (RAST). Paper discs conjugated with chlorhexidine-HSA (human serum albumin) significantly bound the IgE antibodies. Furthermore, all of the sera from seven other patients with shock reactions following the topical application of chlorhexidine preparation also showed high RAST counts. Both chlorhexidine gluconate and chlorguanide which represents approximately half a molecule of chlorhexidine inhibited the reaction in a dose-dependent fashion. It is suggested that the shock reactions following topical application of chlorhexidine are mediated by IgE antibodies against chlorhexidine and that chlorhexidine and chlorguanide share the same antigenic determinant.

  • References9
  • Citations49

References

Mentioned in this Paper

Antigenic Specificity
ALB
Radioallergosorbent Test
Administration, Topical
Immunoglobulin E
Anaphylaxis
Chloriguane
Tubulicid

About this Paper

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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