IgE-dependent sensitization increases responsiveness to LPS but does not modify development of endotoxin tolerance in mast cells.

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Jaciel Medina-TamayoClaudia González-Espinosa

Abstract

Effects of immunoglobulin E (IgE)-dependent sensitization on the response to bacterial lipopolysaccharide (LPS) were analyzed in mast cells. Murine bone marrow-derived mast cells (BMMCs) were sensitized or not with IgE before stimulation with LPS. TLR4 and co-receptors expression was analyzed by flow cytometry and RT-PCR, TNF-α production by ELISA, IKK and IκB activation by western blot or immunoprecipitation. NFκB nuclear translocation was determined by EMSA. IgE-sensitized BMMCs secreted larger amounts of TNF-α than non-sensitized cells shortly after LPS challenge. No change in TLR4, CD14 or MD-2 expression was detected after the IgE-dependent sensitization process, whereas TLR4-dependent phosphorylation of IKK and IκB was augmented. IgE-dependent sensitization increased basal NFκB activity. Endotoxin tolerance was not affected by the IgE-dependent sensitization process. IgE-induced sensitization primes mast cells for higher response to LPS through pre-activation of NFκB transcription factor. IgE-dependent sensitization does not modify events leading to endotoxin tolerance.

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Citations

Aug 7, 2013·Journal of Hematology & Oncology·Guillermina Yanek Jiménez-AndradeClaudia González-Espinosa
Sep 10, 2011·IUBMB Life·Martin Avila, Claudia Gonzalez-Espinosa
Dec 12, 2017·F1000Research·Silvia Monticelli, Cristina Leoni
Mar 1, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Zyanya P Espinosa-RiquerClaudia González-Espinosa
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alejandro Martín-ÁvilaClaudia González-Espinosa
Aug 20, 2017·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·F Guzmán-MejíaC González-Espinosa
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Iris K Madera-SalcedoClaudia Gonzalez-Espinosa
Mar 30, 2020·Journal of Neuroinflammation·Marian Jesabel Pérez-RodríguezClaudia González-Espinosa
Oct 20, 2021·Journal of Neurochemistry·Pablo Eliasib Martínez-GoparFrancisca Pérez-Severiano

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