IgE in childhood asthma: relevance of demographic characteristics and polysensitisation

Archives of Disease in Childhood
M SilvestriG A Rossi

Abstract

Despite the therapeutic efficacy of the anti-IgE monoclonal antibody, the role of IgE in allergic asthma is still a matter of debate. This may be mostly relevant in childhood, where a wide range of total serum (s) IgE levels is often detected. To evaluate whether the relationships between total or allergen-specific sIgE levels and the clinical markers of allergic inflammation and the pulmonary function values might be affected by the demographic characteristics of the patients or by the presence of multiple sensitisations to allergens. 64 asthmatic children sensitised to house dust mites (HDM) were evaluated. The role of age, sex and multiple sensitisations was evaluated by multiple regression model (MRM) analysis. Total and HDM-specific sIgE levels (Log) showed similar moderate-to-strong correlations with exhaled nitric oxide (FENO) and blood eosinophilia (Log) (p<0.0001) but not with forced vital capacity, forced expiratory volume in 1 s (FEV(1)), %FEV(1) change after salbutamol. The positive associations between total sIgE levels and Log FENO levels or Log blood eosinophilia were also detected by MRM analysis. Age brought a negative, although limited, contribution to FENO levels and blood eosinophilia (p<0.043). Positive sim...Continue Reading

Citations

Oct 1, 2011·European Journal of Pediatrics·Anne D RøRoar Johnsen
Jul 22, 2015·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Agnes LuzakHolger Schulz
Nov 6, 2015·Allergy, Asthma & Immunology Research·Maria Angela ToscaGiorgio Ciprandi
Jan 25, 2013·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Cindy M A de BotJohannes C van der Wouden

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