IgE levels in surgery: effect of ranitidine and prednisolone

Allergy
G T KampenL J Petersen

Abstract

Immunoglobulin E (IgE) is important in allergic reactions and in host defense against parasites. IgE may also participate in the acute-phase response to physical stress. This study aimed to determine whether major abdominal surgery induced increased serum IgE levels, and whether treatment with ranitidine or prednisolone influenced the IgE response to surgery. For assessment of the IgE response to surgery and the effect of ranitidine, 24 patients scheduled for major abdominal surgery were randomized to receive either perioperative treatment with ranitidine or no treatment. To evaluate the effect of glucocorticoids, 24 patients undergoing major elective abdominal surgery were randomized to receive preoperative treatment with either prednisolone or placebo. IgE levels were determined in serum samples drawn pre- and postoperatively. In the ranitidine study, both the control group and the ranitidine-treated group displayed a postoperative increase (P<0.001) of serum IgE. In the prednisolone study, a postoperative increase (P<0.05) of serum IgE was detected in the placebo group. No significant increase was found in the prednisolone-treated group. Major abdominal surgery induces an increase of serum IgE. This increase can be prevented...Continue Reading

References

Mar 1, 1979·Clinical Allergy·G J GleichM M Mani
Sep 1, 1978·The Journal of Allergy and Clinical Immunology·G A SettipaneJ H McGowan
Dec 1, 1978·The Journal of Allergy and Clinical Immunology·W C PoseyD S Pearlman
Jan 1, 1992·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·J H HammerH Kehlet
Aug 1, 1991·Annals of Surgery·H TanakaT Sugimoto
Feb 1, 1990·The Biochemical Journal·P C HeinrichT Andus
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M HattoriG H Fey
Jan 1, 1989·International Archives of Allergy and Applied Immunology·J P Dessaint, A Capron
Mar 1, 1989·American Journal of Surgery·H J NielsenH Kehlet
Jun 1, 1988·Circulation·A SzczeklikJ Dropinski
Dec 1, 1987·Burns, Including Thermal Injury·V PolacekR Konigova
Nov 1, 1987·The Journal of Surgical Research·K MealyC Feighery
Sep 1, 1984·Annals of Surgery·C W NohrJ L Meakins
May 1, 1993·Acta Anaesthesiologica Scandinavica·E TønnesenP Toft
Nov 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F H KleblH G Nüsslein
Aug 1, 1994·The Journal of Allergy and Clinical Immunology·G ZiegD Y Leung
Mar 1, 1994·Archives of Surgery·H J NielsenF Moesgaard
Nov 1, 1993·The Journal of Allergy and Clinical Immunology·R M NaclerioP S Norman
Aug 1, 1996·Toxicology Letters·A J Frew
Mar 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A Szczeklik, J Jawień

❮ Previous
Next ❯

Citations

Nov 26, 2002·World Journal of Surgery·Jacek Jawien
Nov 20, 2002·Journal of the American College of Surgeons·Kathrine Holte, Henrik Kehlet
Sep 14, 2007·Annals of Medicine·Lars K Poulsen, Lone Hummelshoj

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

International Archives of Allergy and Applied Immunology
K J TurnerP G Holt
Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
A Szczeklik, J Jawień
International Archives of Allergy and Applied Immunology
B M StadlerA L de Weck
© 2021 Meta ULC. All rights reserved