Abstract
Celiac disease and immediate type hypersensitivity to wheat are immune responses with different pathogenic mechanisms. Both diseases are well known entities but their coexistence in the same patient is rarely reported. This is a unique case presentation of a patient with celiac disease who developed concomitant IgE-mediated wheat allergy and presented with immediate symptoms in two body systems. We report the case of a girl with celiac disease who subsequently developed IgE-mediated hypersensitivity to wheat. The patient is a Caucasian female who was diagnosed with celiac disease at 18 months of age after presenting with recurrent vomiting and failure to thrive. Her anti-tTG antibody level was greater than 200 E.U. and biopsy results from endoscopy were consistent with celiac disease. Specific IgE antibody to wheat was negative at 2 years of age. Around seven years of age, she developed immediate symptoms of urticaria, cough and shortness of breath with accidental exposures to wheat. Specific IgE antibody testing was repeated and positive to wheat (42.5 kU/L), as well as rye (33.9 kU/L), barley (53.4 kU/L) and oat (11.3 kU/L). At 9 years of age, skin prick testing was positive to wheat, barley and rye but negative to oat. The p...Continue Reading
References
Sep 1, 1977·Clinical Allergy·F BjörksténT Kärkkäinen
Mar 1, 1978·Clinical Allergy·B A Baldo, C W Wrigley
Dec 1, 1989·The Journal of Allergy and Clinical Immunology·H A Sampson
Sep 1, 1995·The Journal of Allergy and Clinical Immunology·S M JonesH A Sampson
Feb 1, 1997·The Journal of Allergy and Clinical Immunology·J M JamesA W Burks
Sep 28, 2002·Science·Lu ShanChaitan Khosla
Jan 12, 2008·Allergy·H MatsuoE Morita
Nov 27, 2008·International Archives of Allergy and Immunology·S JacquenetD A Moneret-Vautrin
Dec 17, 2008·Recent Patents on Inflammation & Allergy Drug Discovery·Alicia ArmentiaAlfredo Blanco
Feb 13, 2009·Allergy·C ConstantinR Valenta
Oct 4, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Rumiko ShibataEishin Morita
Feb 9, 2012·BMC Medicine·Anna SaponeAlessio Fasano
Apr 3, 2012·The Journal of Allergy and Clinical Immunology·Gideon Lack
Dec 18, 2013·The Journal of Allergy and Clinical Immunology·Alexandra BaarRudolf Valenta