IgE-mediated anaphylaxis to Thiomucase, a mucopolyssacharidase: allergens and cross-reactivity

Allergy
T CaballeroM C López-Serrano

Abstract

Thiomucase is a mucopolysaccharidase obtained from ovine tissues mainly used to facilitate the diffusion of local anaesthetics and in the treatment of cellulitis. A patient with an anaphylaxis in relation to the intramuscular administration of Thiomucase is reported. To investigate Thiomucase allergens and their possible relationship with dander allergens and animal albumins. Skin prick tests (SPT) and serum-specific IgE were performed with Thiomucase and danders. Thiomucase SDS-PAGE immunoblotting was performed in order to study allergens. RAST/CAP inhibition and SDS-PAGE immunoblotting inhibition were carried out to study the cross-reactivity. Skin prick tests (SPT) were positive to Thiomucase, animal dander (cat, dog, sheep, other), bovine serum albumin (BSA), and echinococcus. Specific IgE was also positive to Thiomucase, animal dander (cat, dog, sheep, other), BSA and echinococcus. In the RAST-CAP inhibition assays BSA was nearly completely inhibited by Thiomucase, Thiomucase was partially inhibited by BSA and cat and Echinococcus granulosus was partially inhibited by sheep and Thiomucase. In the Thiomucase SDS-PAGE immunoblotting several proteins fixed IgE, ranging from 20 kDa to > 94 kDa, the strongest with 43 kDa. The I...Continue Reading

References

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Citations

Aug 3, 2011·Current Allergy and Asthma Reports·Gennaro LiccardiGennaro D'Amato
May 18, 2004·Clinical Reviews in Allergy & Immunology·Dominique A Vuitton
Sep 17, 2005·European Journal of Anaesthesiology·F EscolanoB Bartolomé
Dec 1, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·Teoman Zafer Apan, Sedat Kaygusuz

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Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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