PMID: 7333765Mar 1, 1981Paper

IgE mediated hypersensitivity in children with idiopathic nephrotic syndrome

The International Journal of Pediatric Nephrology
W RebienK Schärer

Abstract

Sixty children with idiopathic nephrotic syndrome (NS) and 30 unselected controls were studied for IgE mediated hypersensitivity by skin-test, total serum IgE and specific IgE antibodies to various allergens. In 42 patients the NS was steroid-responsive and associated with minimal glomerular changes (MC); in 18 patients it was steroid-resistant and associated with focal-segmental glomerulosclerosis (FSS). A history of allergy was found in 17% of MC, 6% of FSS and 10% of control children. Neither serum IgE concentration nor the incidence of allergen specific IgE antibodies were significantly different between the 3 groups. In the presence of steroid-dependency the prevalence of atopy appeared to be higher. However, our data do not support the hypothesis that for the pathogenesis of NS IgE mediated hypersensitivity plays a general role.

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

Proceedings of the European Dialysis and Transplant Association
V LenhardK Schärer
Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
You-Lin TainKuender D Yang
The International Journal of Pediatric Nephrology
E B Trainin, G Gomez-Leon
© 2021 Meta ULC. All rights reserved